WirelessTechnology Assisted Weight Management in Pre-Diabetic Adolescents...

项目总结（见说明）： 超重/肥胖的患病率存在显著差异，非洲裔美国城市青少年和年轻人普遍受到影响。他们中的许多人发展为2型糖尿病前期的代谢特征，如果不进行干预，最终会发展为2型糖尿病。 需要行为干预来激励行为改变，减轻体重，并最终预防2型糖尿病的发展。手机短信已经显示出承诺，在从事糖尿病青年和年轻人自我监测他们的血糖。手机是便携式的，被青少年和年轻人广泛使用和接受。令人兴奋的初步证据表明， 支持网络的手机技术对于成人糖尿病患者的管理非常有用。拟议研究的总体目标是实施并严格评估这一创新计划在青少年中的预防获益，该计划成功应用于成人患者管理，包括最先进的通信和网络技术。为了实现这一目标，本提案的具体目的是比较使用最先进的通信和网络技术或使用生活方式团体访问提供的生活方式改变干预措施的有效性。18-24岁的年轻人诊断为2型糖尿病前期将被转介到霍华德大学医院糖尿病治疗中心参与本项目。参与者将从霍华德大学医院的诊所招募，这是一家为少数民族服务的机构。符合条件且同意的青少年将随机分配至上述2个治疗组之一。患者激活的有效测量将是主要结局，并在基线、干预后3个月、6个月和1年进行评估。将评估组内和组间变化，并在相同时间点监测其他生物生理学结局（体重指数和血红蛋白AlC）。研究结果对解决早期健康发病率的重要差异具有重要意义。我们的分析将测试 通过网络支持的PHR和教育门户获得健康信息的手机技术的扩展，有望成为有2型糖尿病风险的非洲裔美国晚期青少年/年轻人的预防干预措施。

PROJECT SUMMARY (See instructions): There are significant disparities in the prevalence of overweight/obesity, with African-American urban adolescents and young adults commnonly affected. Many of them develop metabolic arrangements characteristic of pre-type 2 diabetes and, without intervention, eventually progress to type 2 diabetes. Behavioral interventions are required to motivate behavioral change, reduce weight, and eventually prevent the development of type 2 diabetes. Cell phone text messaging has already shown promise in engaging diabetic youth and young adults to self monitor their blood glucose. Cell phones are portable, widely used and accepted by adolescents and young adults. Exciting preliminary evidence is available suggesting that use of Web-enabled cell phone technology is useful in the management of adult patients with diabetes. The overall objective of the proposed study is to implement and rigorously evaluate the preventive benefits in adolescents of this innovative program successfully applied in adult patient management that includes state of- the-art communications and networking technologies. To achieve this objective, the specific aim of this proposal is to compare the effectiveness of a lifestyle change intervention delivered either using state-of-theart communications and networking technologies or using Lifestyle Group Visits. Young adults 18-24 years of age with a diagnosis of pre- type 2 diabetes will be referred to the Howard University Hospital Diabetes Treatment Center for participation in this project. Participants will be recruited from clinics at Howard University Hospital, a minority-serving institution. Eligible and consenting youth will be randomized to one of the 2 treatment groups as described above. A validated measure of patient activation will be the primary outcome, and be assessed at baseline, three months, six months and one year following intervention. Both within and between group changes will be assessed, and additional biophysiologic outcomes (body mass index and hemoglobin AlC) will also be monitored at the same time points. Study findings have significant implications in addressing an important disparity in early health morbidity. Our analyses will test whether the extension of cell phone technology with access to health information through web-enabled PHR'and educational portals yield promise as a preventive intervention among African American late adolescents/young adults at risk for type 2 diabetes.