Genetic and epigenetic controls of gene regulation
Genetic and epigenetic controls of gene regulation
批准号:
8701329
负责人:
JONATHAN K PRITCHARD
金额:
$38.67万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-09-17 至 2016-06-30
关键词:
Active SitesAffectArchitectureBase PairingBase SequenceBindingBiologicalBiological AssayChromatinCommunitiesComplexComputing MethodologiesDNA MethylationDNA SequenceDataData AnalysesData SetDiseaseElementsEpigenetic ProcessGene ExpressionGene Expression RegulationGeneticGenetic VariationGenomicsHistonesIndividualMessenger RNAMethodsModelingNucleic Acid Regulatory SequencesNucleosomesOrganismOutputPaperPhenotypePlayPositioning AttributeProteinsPublishingRegulator GenesRegulatory ElementReporter GenesResearch PersonnelResolutionRoleScientistSignal TransductionSiteStatistical MethodsStatistical ModelsTechnologyTestingTissuesValidationVariantWorkanalytical toolcell typecomputerized toolsexperiencegenome wide association studygenome-widehistone modificationimprovedinsighttranscription factor
中文摘要
描述(由申请人提供):我们建议开发统计和计算方法来解释ENCODE项目中各种细胞类型的基因调控数据。我们的工作将集中在(I)开发集成许多组织中的不同数据类型以推断染色质结构的方法;(Ii)推断不同细胞类型染色质差异的序列决定因素和调控结果;以及(Iii)使用自然遗传变异和实验方法对我们的预测进行实证测试。
英文摘要
DESCRIPTION (provided by applicant): We propose to develop statistical and computational methods for interpreting data on gene regulation in a variety of cell types from the ENCODE Project. Our work will focus on (i) developing methods for integrating diverse data types in many tissues to infer chromatin architecture; (ii) inferring the sequence determinants and regulatory consequences of differences in chromatin across cell types; and (iii) empirical tests of our predictions using both natural genetic variation and experimental approaches.
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海外基金