Center of Excellence for Mobile Sensor Data-to-Knowledge (MD2K) - OVERALL

描述(申请人提供)：技术的快速进步导致了可现场部署的移动传感设备，现在可以用来量化关键的物理、生物、行为、社会和环境因素在一段时间内的复杂动态 健康和疾病风险。这些数据将使我们能够突破对复杂疾病病因的生物医学理解的下一个水平。虽然目前在基因组学、成像和电子病历领域的“大数据”分析方面取得了重大进展，但还需要大量的新投资来开发和传播针对移动传感器数据的独特特征(例如，大容量、速度、多样性、可变性和多功能性)的数据分析工具，以将这些丰富的数据转化为信息、知识和行动。在这个早期阶段，投资于强大的、开放的、科学的和计算基础设施，以促进科学和改善健康，有望带来超高的回报。移动传感器数据到知识卓越中心(MD2K)将产生可推广的理论、方法、工具和软件，以解决处理复杂的移动传感器数据及其在生物医学知识发现和即时护理提供中使用的主要障碍，为P5医学奠定基础。它将开发和实施一个基于标准、可互操作、可扩展和开放源码的大数据软件平台，以有效实施MD2K数据分析。MD2K中心将通过在两个生物医学应用的背景下实施整个MD2K数据分析系统来展示MD2K方法的可行性、实用性和普适性--减少每日戒烟者的复发和减少充血性心力衰竭(CHF)患者的再入院。该中心开发的所有工具和软件将以符合标准和开放源代码的形式免费提供，并提供文档，以促进数据科学研究人员推进MD2K的科学及其与其他生物医学大数据的集成，如电子病历、基因组学和成像。该中心将提供培训材料，帮助生物医学研究人员在他们的移动设备和服务器上安装MD2K软件，以收集移动传感器数据并分析这些数据，以用于生物医学发现。

DESCRIPTION (provided by applicant): Rapid advances in technology, are leading to field-deployable mobile sensing devices that can now be used to quantify complex dynamics across time of key physical, biological, behavioral, social, and environmental factors that contribute to health and disease risk. These data will enable us to break through to the next level of biomedical understanding of causation in complex disorders. While ongoing efforts have made significant strides in the analysis of "big data" in the areas of genomics, imaging, and EHR, significant new investment is needed to develop and disseminate data analytics tools specific to the unique features of mobile sensor data (e.g., high volume, velocity, variety, variability, and versatility) to convert this wealth of data into information, knowledge, and action. Investment in strong, open, scientific, and computational infrastructure for mobile "big data" at this early stag promises outsize returns to advance science and improve health. The Center of Excellence for Mobile Sensor Data-to-Knowledge (MD2K) will generate generalizable theory, methods, tools, and software, to address major barriers to processing complex mobile sensor data and its use in biomedical knowledge discovery and just-in-time care delivery, laying the foundation for P5 Medicine. It will develop and implement a standards-based, interoperable, extensible and open-source big data software platform for efficient implementation of MD2K data analytics. The MD2K Center will demonstrate the feasibility, utility, and generalizability of the MD2K approach by implementing the entire MD2K data analytics system in the context of two biomedical applications - reducing relapse among abstinent daily smokers and reducing readmission among congestive heart failure (CHF) patients. All the tools and software developed by the Center will be freely available as standards-compliant and open-source with documentation to engage data science researchers in advancing the science of MD2K and its integration with other biomedical big data such as EHRs, genomics, and imaging. The Center will provide training materials to help biomedical researchers install the MD2K software on their mobile devices and servers to collect mobile sensor data and analyze these data for biomedical discovery.