A Chiang Mai University - HMRI MRI/MRS Project: A Neurobiology Study of Methamphe

简介(由申请人提供)：由于泰国清迈大学放射科技系采用最先进的磁共振技术及其新安装的1.5T飞利浦磁共振扫描仪，并为提升及扩展本地在磁共振技术方面的专业知识，本建议得以实施。在临床研究环境中缺乏对MRI和MRS方法的当地知识，这是目前当地对艾滋病毒/艾滋病和药物滥用的临床研究感兴趣的一个主要障碍。这项建议的第一个目标是建立适合长期临床研究的磁共振技术的本地专业知识。将加强对泰国北部当地磁共振物理学家、医疗保健专业人员和技术人员的培训和指导，并为在这种资源有限的情况下继续发展学术放射学提供支持。本建议中选择的临床研究主题利用了清迈大学RIHES部门目前在艾滋病毒/艾滋病和药物滥用流行病学调查方面积极开展的临床研究。它缺乏关于艾滋病毒感染和药物滥用对中枢神经系统(CNS)影响的神经生物学专业知识。这项提议将填补这一空白。标准的脑MRI和MRS数据将与少数感染艾滋病毒的受试者、甲基苯丙胺滥用者和合并疾病的受试者一起收集。这些数据将作为初步数据，为随后的R01拨款申请建立中枢神经系统功能障碍假说。

DESCRIPTION (provided by applicant): Due to the availability of state-of-the-art MR technology with its newly installed 1.5T Philips MR scanner at the Department of Radiological Technology, Chiang Mai University, Thailand and with the purposes of advancing and expanding local expertise in MR technology this proposal has been made possible. The lack of local knowledge on MRI and MRS methods in clinical research setting is proving to be a major barrier for the current local interest in clinical research in HIV/AIDS and drug abuse. The first aim of this proposal is to build local expertise in MR technology suitable for long term clinical research. Training and mentoring of local MR physicists, healthcare professionals and technicians in Northern Thailand will be enhanced and support provided for the continued development of academic radiology in this resource limited setting. The clinical research topics chosen in this proposal take advantage of the current active clinical research in epidemiological investigations in HIV/AIDS and drug abuse at the RIHES unit of Chiang Mai University. It lacks expertise in neurobiology of the effect of HIV infection and drug abuse on the central nervous system (CNS). This proposal will fill that gap. Normative brain MRI and MRS data will be collected along with a small number of subjects who are HIV infected, methamphetamine abusers, and subjects with co- morbidities. These data will serve as preliminary data to develop hypothesis in the dysfunction of CNS for subsequence R01 grant application.