International Society for Extracellular Vesicles - Education Day & Meeting

 描述(申请人提供)：此R13申请支持国际细胞外小泡协会(ISEV)将于2015年4月22-26日在北贝塞斯达万豪酒店举行的第四届国际会议。“细胞外小泡：转化基础科学来解决人类疾病”会议将把巴尔的摩/华盛顿医疗和生物技术社区的美国临床医生聚集在一起，将ISEV的700名基础科学家的工作转化为临床护理。细胞外小泡(EV，包括“外体”、“微泡”、凋亡体和其他)直径从30纳米到1微米不等，含有来自起源细胞的蛋白质、脂类、RNA和代谢物。EV作用于局部组织，但也可分泌到生物液中并可从生物液中提纯。ISEV 2015将涉及免疫调节、艾滋病毒/艾滋病、抗原呈递、凝血、组织重塑、EV在癌症转移中的作用、作为肿瘤特异性蛋白质和RNA突变携带者的诊断和预后，以及治疗的交付。会议将从4月22日的教育日开始，与NIH共同基金细胞外RNA传播联盟合作，从临床样本中分离EV。教育日将包括由学术界和业界代表主持的口头演讲和技术研讨会。主要会议于4月23日至26日举行，2013年诺贝尔奖得主詹姆斯·罗斯曼将发表主旨演讲。美国国立卫生研究院的弗朗西斯·柯林斯和哈佛大学的电动汽车先驱桑德拉·布雷克菲尔德也被邀请担任全体演讲者。将举行三次平行的口头会议，共27次专题会议，将讨论电动汽车和医学研究中的紧迫问题。一个著名的国际小组，包括ISEV细胞外小泡杂志的编辑和DC地区的研究人员，将审查提交的摘要，以分配100多个口头陈述和300多个按主题分组的海报。向代表性不足的少数群体、妇女以及年轻和早期调查人员提供便利和服务是优先事项。教育日和全体会议将通过网络向医学生、相关领域的研究人员和代表性不足的少数族裔机构进行广播。ISEV计划向代表性不足的少数群体成员和年轻调查人员提供15项旅行奖学金。会议中心完全无障碍，符合ADA标准。将为哺乳母亲设立专门的房间，并将在ISEV网站和现场提供有关儿童或依赖老人的日托选择的信息。ISEV 2015会议和支持会议的R13将接待750-1000名与会者，并强调定义和隔离EV及其亚型的共识标准；争取就制备和分离技术以及标准化标本生物库达成协议；加强现有联盟，并在肿瘤学和传染病等领域的生物标记物验证和治疗研究方面建立新的合作伙伴关系。没有其他会议提供2015年国际电动汽车会议的范围和参与情况，以解决电动汽车领域的及时问题。ISEV 2015提供了一个机会，将ISEV基础和临床科学家的国际强度与充满活力和不断增长的美国电动汽车研究人员社区结合起来，这肯定是2015年电动汽车领域最具影响力的活动。

 DESCRIPTION (provided by applicant): This R13 application supports the Fourth International Meeting of the International Society for Extracellular Vesicles (ISEV) to be held at the Bethesda North Marriott from April 22-26, 2015. The meeting "Extracellular Vesicles : translating basic science to address human disease" will bring together American clinicians from the Baltimore/Washington medical and biotechnology communities to translate to clinical care the work of the 700 basic scientists of ISEV. Extracellular Vesicles (EV, including "exosomes," "microvesicles," apoptotic bodies, and others) range in diameter from 30 nm to one micron and containing proteins, lipids, RNA, and metabolites derived from the cell of origin. EV act locally i tissues but are also secreted into and can be purified from biofluids. ISEV 2015 will address immune regulation, HIV/AIDS, antigen presentation, coagulation, tissue remodeling, the role of EV in cancer metastasis, diagnosis and prognosis as carriers of tumor-specific protein and RNA mutations, and delivery of therapies. The meeting will begin with an Educational Day, April 22, on isolation of EV from clinical samples, in cooperation with the NIH Common Fund Extracellular RNA Communication Consortium. The Educational Day will feature oral presentations as well as technical workshops led by academic and industry representatives. The main meeting, from April 23-26, will witness a keynote speech by 2013 Nobel Laureate James Rothman. Francis Collins of NIH and EV pioneer Xandra Breakefield of Harvard have also been invited as plenary speakers. Three parallel oral sessions will take place, with a total o 27 thematic sessios, will address pressing issues in EV and medical research. A distinguished international panel, including the editors of ISEV's Journal of Extracellular Vesicles and DC-area researchers, will review submitted abstracts for assign more than 100 oral presentations and 300 thematically-grouped posters. Accessibility and service to underrepresented minorities, women, and young and early stage investigators are priorities. The Educational Day and plenary sessions will be web-broadcast to medical students, researchers in allied fields and underrepresented minority institutions. ISEV plans to provide fifteen traveling fellowships to members of underrepresented minority groups and young investigators. The Conference Center is fully accessible and ADA compliant. A dedicated room will be set up for nursing mothers, and information about daycare options for children or dependent seniors will be offered on the ISEV website and on-site. The ISEV 2015 meeting and the R13 that supports it will host 750-1000 attendees and emphasize consensus standards by which to define and isolate EV and their subtypes; strive for agreements on preparative and isolation techniques and normative specimen biorepositories; and strengthen existing consortia and establish new partnerships for biomarker validation and treatment studies in oncology and infectious diseases, among others. No other meeting offers the scope and participation of ISEV 2015 to address timely questions in the EV field. ISEV 2015 provides an opportunity to combine the international intensity of ISEV's basic and clinical scientists with the vibrant and growing American community of EV investigators in what will surely be the most influential event of 2015 in the EV field.