Training in the Molecular Biology of Neurodegeneration

描述（由申请人提供）：我们建议继续一个非常成功的神经变性分子生物学培训计划，该计划致力于培养博士后和博士生，使其成为大学和健康相关研究实验室的独立研究科学家。培训师都是哈佛大学的教职员工，他们在神经退行性疾病方面有着积极的研究项目，重点是阿尔茨海默病和其他与衰老相关的神经退行性疾病。他们来自哈佛医学院和六家附属研究医院：贝斯以色列女执事医疗中心、布里格姆妇女医院、儿童医院、丹娜法伯癌症研究所、马萨诸塞州总医院和麦克莱恩医院。该项目的教师包括分子生物学家、遗传学家、细胞生物学家、神经病理学家和生物化学家，他们为与年龄相关的神经变性问题带来了广泛的经验和实验方法。这些博士生是从哈佛医学院授予学位的神经科学项目的研究生中招募和抽取的。博士后学生从该计划的个别教员提名的申请人中选择。受训者的选拔是通过一个由培训补助金咨询委员会调解的竞争性程序进行的。共有6名博士前培训生和8名博士后培训生，为28名具有年龄相关神经变性基础和应用研究经验的人员提供初级培训。在所有情况下，成功候选人的主要标准是对衰老和神经变性研究的奉献精神和兴趣，以及在以前的培训中取得的最高水平的学术成就。学生需要参加特殊的神经变性课程、研讨会、期刊俱乐部和专题讨论会。密切监测学生的进步和职业建议为整个培训过程提供了有效的结构。该计划的目的是建立一个框架，在这个框架内，未来致力于衰老和神经变性问题的研究人员可以得到最好的培训，并且项目教师之间已经广泛的合作互动可以在各个层面上传播，从学生到教授。

DESCRIPTION (provided by applicant): We propose to continue a highly successful Training Program in the Molecular Biology of Neurodegeneration - a program devoted to the training of pre- and postdoctoral students for careers as independent research scientists in universities and health-related research laboratories. The trainers are all Harvard faculty members with active research programs related to neurodegeneration, with an emphasis on Alzheimer's disease and other neurodegenerative disorders related to aging. They are drawn from the Harvard Medical School and six affiliated research hospitals: Beth Israel-Deaconess Medical Center, Brigham and Women's Hospital, Children's Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital, and McLean Hospital. Bringing a wide range of experience and experimental approaches to the problems of age-related neurodegeneration, the Program faculty includes molecular biologists, geneticists, cell biologists, neuropathologists, and biochemists. The predoctoral students are recruited into and drawn from the graduate students in the degree-granting Neuroscience Program of the Harvard Medical School. The postdoctoral students are chosen from among applicants nominated by individual faculty members of the Program. Selection of trainees occurs through a competitive process mediated by a Training Grant Advisory Committee. A total of six predoctoral trainees and eight postdoctoral trainees are proposed for a primary training faculty of 28 individuals experienced in basic and applied studies of age-related neurodegeneration. In all cases, the main criteria for successful candidates is dedication and interest in aging and neurodegeneration research and the highest level of academic achievement in their previous training. Students are required to participate in special neurodegeneration courses, seminars, journal clubs and symposia. Close monitoring of student progress and career advising provide an effective structure for the entire training process. The purpose of the Program is to create a framework within which the best training of future researchers devoted to problems in aging and neurodegeneration can take place, and the already extensive collaborative interactions among the Program faculty can be propagated at all levels, from student to Professor.