HIV-TB Fogarty Research Training Program

描述（由申请人提供）：本提案建立在一个20年的福格蒂艾滋病国际培训和研究项目（AITRP）的成功基础上，该项目支持了印度浦那的机构艾滋病研究能力建设。自1992年以来，霍普金斯大学印度福格蒂AITRP在霍普金斯大学培训了103名印度科学家，从事广泛的流行病学和基础科学研究项目，其中99名（95%）返回印度应用他们在福格蒂的研究培训。福格蒂AITRP直接导致在国家艾滋病研究所（NARI）和Byramjee Jeejeebhoy医学院（BJMC）建立了高效、成功和可持续的艾滋病毒研究项目。BJMC还参与了20年来美国国立卫生研究院支持的HIV研究，现在是一个完善的临床试验单位（CTU）。我们现在提议，在这个申请中，战略性地扩大BJMC在HIV-TB流行病学、临床和实验室研究方面的机构研究能力和科学领导地位。艾滋病-结核病研究培训计划将由Bob Bollinger博士领导，他在过去二十年担任印度福格蒂AITRP主任。他将与BJMC医学系主任D. B. Kadam博士密切合作，后者将担任Fogarty HIV-TB研究培训计划的协调员。博士后培训计划分为三个阶段，包括短期和长期战略培训活动、指导研究项目、研究研讨会以及在北京jmc建立数据管理和生物统计学培训核心。在第一阶段（第一年和第二年），10名BJMC教师（6名流行病学/临床研究人员和4名实验室实习生）将参加战略性短期培训活动。第一阶段的成功完成将为这10名教师提供竞争第二阶段培训（2 -4年）的机会，其中包括4个深度培训机会（2个受指导的公共卫生硕士学位项目和2个受指导的博士后实验室研究奖学金）。这4名第二阶段的教员学员将负责在第三阶段（第五年）建立BJMC HIV-TB研究领导团队，通过他们自己作为另外5名BJMC教员学员的导师参与，该团队将展示可持续的机构能力。这个艾滋病-结核病培训项目的设计反映了过去20年来在印度建立机构研究能力方面获得的重要经验教训。经验丰富的培训咨询委员会（TAC）的领导，14名经验丰富的霍普金斯大学教师导师的参与，包括2名在浦那的全职霍普金斯大学教师，以及霍普金斯大学临床全球健康教育中心的远程学习基础设施和经验，也将优化我们项目的影响。与我们之前的AITRP计划一样，该计划的成功将通过同行评审的出版物来证明，特别是福格蒂学员的手稿，由福格蒂领导团队提交的赠款和机构领导的示范以及其他教职员工和学生的当地指导。

DESCRIPTION (provided by applicant): This proposal builds upon the success of a 20-year, Fogarty AIDS International Training and Research Program (AITRP) that supported institutional HIV research capacity building in Pune, India. Since 1992, the Hopkins India Fogarty AITRP has trained 103 Indian scientists at Hopkins, in a wide range of epidemiology and basic science research programs, of whom 99 (95%) returned to India to apply their Fogarty research training. The Fogarty AITRP has led directly to the establishment of highly productive, successful and sustainable HIV research programs at the National AIDS Research Institute (NARI) and Byramjee Jeejeebhoy Medical College (BJMC). BJMC has also participated in 20 years of continuous HIV NIH-supported research and is now a well- established Clinical Trials Unit (CTU). We now propose, in this application, to strategically expand the institutional research capacity and scientific leadership at BJMC in HIV-TB epidemiology, clinical and laboratory research. The HIV-TB Research Training Program will be led by Dr. Bob Bollinger, the India Fogarty AITRP Director for the past two decades. He will work closely with Dr. D. B. Kadam, Head of the Department of Medicine at BJMC, who will be the Coordinator of the Fogarty HIV-TB Research Training Program. A 3 Phase post-doctoral training program for junior and midlevel BJMC faculty will include strategic short- and long-term training activities, mentored research projects, research workshops and establishment of a Data Management and Biostatistics Training Core at BJMC. During Phase I (Years 1 and 2) ten BJMC faculty (6 epidemiology/clinical research and 4 lab trainees) will participate in strategic short-term trainin activities. Successful completion of Phase I will provide these 10 faculty an opportunity to compete for Phase II training (Years 2-4), which will include 4 in-depth training opportunities (2 mentored MPH degree programs and 2 mentored postdoctoral laboratory research fellowships). These 4 Phase II faculty trainees will then be responsible establishing The BJMC HIV-TB Research Leadership Team during Phase III (Year 5), which will demonstrate sustainable institutional capacity through their own participation as mentors for 5 additional BJMC faculty trainees. The design of this HIV-TB training program reflects key lessons learned over the past 20 years about building institutional research capacity in India. The impact of our program will also be optimized by the leadership of a highly experienced Training Advisory Committee (TAC), by participation 14 experienced Hopkins faculty mentors, including 2 full-time Hopkins faculty based in Pune, as well as the distance learning infrastructure and experience of the Hopkins Center for Clinical Global Health Education. As with our prior AITRP program, success of this program will be demonstrated by peer-reviewed publications, particularly manuscripts first-authored manuscripts by Fogarty trainees, grant submissions and demonstration of institutional leadership and local mentorship of other faculty and students, by the BJMC Fogarty Leadership Team.