Key Role of Connective Tissue Growth Factor (CTGF) in Familial Cardiomyopathy and Heart Failure
Key Role of Connective Tissue Growth Factor (CTGF) in Familial Cardiomyopathy and Heart Failure
批准号:
nhmrc : 632576
负责人:
Dr Tatiana Tsoutsman
金额:
$26.34万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2013-12-31
中文摘要
家族性心肌病是导致心力衰竭和猝死的重要原因。了解疾病如何在心肌病中发展的确切机制是开发新的治疗和预防策略的重要一步。我们计划研究结缔组织生长因子(CTGF)在易患心脏病的细胞、小鼠和人类中的作用。结缔组织生长因子是一种导致心脏瘢痕形成的重要蛋白质。
英文摘要
Familial cardiomyopathies are an important cause of heart failure and sudden death. Understanding the precise mechanisms of how disease develops in cardiomyopathies is an important step for developing new therapeutic and prevention strategies. We plan to investigate the role of connective tissue growth factor (CTGF) , an important protein which causes scar formation in the heart, in cells, mice, and humans predisposed to developing heart disease.
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