Impact of drug use on HIV/STI risk across development among African American female adolescents: An integrative data analysis

 描述（由申请人提供）：拟议研究的总体目标是更准确地了解美国南部非洲裔美国女性青少年中与药物相关的艾滋病毒和性传播感染（STI）风险。这项拟议的研究将使用综合数据分析（IDA）方法，汇集和协调在非裔美国女性青少年中进行的4项已完成的艾滋病毒/性传播感染预防试验的现有数据。IDA是一个框架，用于对来自多项研究的数据进行同步分析。该研究小组将使用加速纵向设计，一种按年龄连接多个队列的方法，以评估整个青春期药物使用与艾滋病毒/性传播感染风险之间的发育关系。具体而言，拟议的研究将1）创建一个汇总数据集，其中包含协调变量和相应的代码本，这些数据来自在14-24岁的非裔美国女性青少年（N= 2，243）中进行的4项艾滋病毒/性传播感染预防干预试验。然后，该研究将使用合并的协调数据集：2）检查药物使用行为对性风险行为自然过程的影响（例如，多个性伴侣、不使用避孕套的阴道性交）; 3）检查吸毒行为对青少年发育过程中性传播感染自然过程的影响; 4）评估艾滋病毒/性传播感染预防干预措施在多大程度上减少了青少年发育过程中的吸毒行为。这项研究的结果将有助于推进干预措施，以减少南部非洲裔美国青少年女性中与毒品有关的艾滋病毒/性传播感染风险。

 DESCRIPTION (provided by applicant): The overarching goal of the proposed research is to yield a more precise, developmental understanding of drug-related HIV and sexually transmitted infection (STI) risk among African American female adolescents in the Southern United States. The proposed study will use an integrative data analysis (IDA) approach to pool and harmonize existing data from 4 completed HIV/STI prevention trials conducted among African American female adolescents. IDA is a framework for conducting simultaneous analysis of data pooled from multiple studies. The study team will use an accelerated longitudinal design, a method for linking multiple cohorts by age, to assess developmental relationships between drug use and HIV/STI risk across adolescence. Specifically, the proposed research will 1) create a pooled data set with harmonized variables and corresponding codebook combining data from 4 HIV/STI prevention intervention trials conducted among African American female adolescents aged 14-24 years (N=2,243). The study will then use the pooled, harmonized dataset to: 2) examine the influence of drug use behaviors on the natural course of sexual risk behavior (e.g., multiple sexual partners, vaginal sex without a condom) across adolescent development; 3) examine the influence of drug use behaviors on the natural course of STI acquisition across adolescent development and 4) evaluate the extent to which HIV/STI prevention interventions reduce drug use behaviors across adolescent development. Findings from this research will be useful for advancing interventions to reduce drug-related HIV/STI risk among African American adolescent females in the South.