Kinomics and Synaptic Vesicle Endocytosis

癫痫和阿尔茨海默病等脑部疾病与突触的激活有关，突触是神经细胞之间的接触点。突触在胞吞和胞吐的循环过程中吸收和释放神经递质，从而实现神经细胞间的通讯。这项研究的目的是确定主控制器，蛋白激酶，这是在每个周期后重置过程所必需的。这些蛋白可以作为治疗常见神经系统疾病的药物发现项目的靶点。

Brain diseases such as epilepsy and Alzheimer�s are linked to the activation of synapses, contact points between nerve cells. Synapses absorb and release neurotransmitters in the cyclic process of endocytosis & exocytosis allowing nerve cell communication. This study aims to identify the master controllers, protein kinases, which are essential to reset the process after each cycle. These proteins can be exploited as targets in drug discovery programs to treat common neurological diseases.