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Vaccination design based on natural env genes to elicit broad neutralizing Abs

Vaccination design based on natural env genes to elicit broad neutralizing Abs
基于天然 env 基因的疫苗设计可引发广泛的中和抗体
批准号：
8913417
负责人：
Nancy L Haigwood
金额：
$35.47万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-07-16 至 2016-06-30
来源：
https://reporter.nih.gov/project-details/8913417
关键词：
AntigensAutologousComplement component C1DNA VaccinesDevelopmentGaggingGenesHIVHIV vaccineImmune responseImmunityIn VitroIndividualOryctolagus cuniculusPatientsPlasmaPopulations at RiskRecombinant DNASamplingSeveritiesSubunit VaccinesTestingVaccinatedVaccinationVaccinesVariantViral GenomeWorkbasecohortcomparativedesignenv Genesenv Glycoproteinsgp160immunogenicityneutralizing antibodynovel vaccinesprogramsresearch studyresponse

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中文摘要
翻译
该项目寻求开发新型疫苗，可以作为DNA疫苗的组成部分来生产 强中和抗体。如果成功，这些疫苗产生的免疫力可以得到优化。 然后与其他艾滋病毒疫苗一起工作，为高危人群接种疫苗，并减少 感染或严重感染艾滋病毒。
英文摘要
This project seeks to develop novel vaccines that can be delivered as DNA vaccine components to produce strong neutralizing antibodies. The immunity produced by these vaccines, if successful, can be optimized and then tailored to work in combination with other HIV vaccines to vaccinate at-risk populations and reduce acquisition or severity of HIV.
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