Early risk assessment through mathematical modeling of quantitative placental anatomic/structural biomarkers

 描述（由申请方提供）：胎盘测量的圆形度、脐带插入中心性、体积、形状和厚度是母胎生长的生物标志物。即使早在11-14周，与预期胎盘形态的偏离也与胎盘功能障碍和妊娠并发症有关，如先兆子痫、妊娠高血压、妊娠糖尿病和胎儿染色体缺陷。这些偏差的普遍发生揭示了需要数学模型来量化胎盘形态学的偏差，并评估妊娠早期不良妊娠结局的风险。为了满足这一需求，我们组建了一个由胎盘形态学、数学、计算机科学和妇产科专家组成的领先团队，以1）开发和2）验证数学模型，这些模型可以从妊娠早期获得的胎盘形态学测量结果中预测胎盘功能障碍和妊娠并发症。该算法将从一个大型数据库中开发，该数据库由来自妊娠的3D超声胎盘图像组成，具有已知的结果，提供客观标准，其中可以建立胎盘生长的“健康”和潜在的“风险”模式。将推进临床软件原型，以容纳拟议模型，允许输入个体患者数据，并生成不良结局风险增加的估计值，从而指示患者进行进一步研究。所提出的模型将对个体化的妊娠风险进行分类，为管理每次妊娠的个性化计划提供基础。

 DESCRIPTION (provided by applicant): Placental measures of roundness, cord insertion centrality, volume, shape, and thickness are biomarkers of maternal-fetal growth. Deviations from expected placental morphology even as early as 11-14 weeks are related to placental dysfunction and pregnancy complications such as preeclampsia, pregnancy hypertension, gestational diabetes mellitus, and fetal chromosomal defects. The common occurrence of these deviations reveals the need for mathematical models to quantify deviations in placental morphology and assess risk of adverse pregnancy outcomes early in pregnancy. To meet this need, we have assembled a leading team of experts in placental morphology, mathematics, computer science, and obstetrics and gynecology to 1) develop and 2) validate mathematical models that predict placental dysfunction and pregnancy complications from placental morphology measurements obtained early in pregnancy. The algorithm will be developed from a large database comprised of 3D ultrasound placental images from pregnancies with known outcomes providing objective criterion in which "healthy" and potentially "at risk" patterns of placental growth can be established. A prototype for clinical software will be advanced to house the proposed models, allow for inputting of individual patient data, and generate estimates for increased risk for adverse outcomes thereby indicating patients for further investigation. The proposed models will classify individualized pregnancy risks providing a foundation for a personalized plan to manage each pregnancy.