NAVBO Workshops at Vascular Biology 2015

 描述（由申请人提供）：2015年10月18日至22日在马萨诸塞州海恩尼斯度假村和会议中心举行的血管生物学NAVBO研讨会。 主要研究者：Martin Schwartz和Marsha Rolle。血管生物学在过去的十年中已经发展成为一个主要的跨学科研究领域，其影响了许多超出更“传统”的血管壁病理学的主要人类疾病，例如动脉粥样硬化和高血压。今天，血管生物学也有助于我们了解糖尿病，代谢综合征，慢性肾脏疾病，神经系统疾病，中风，血液系统疾病，癌症和各种免疫性疾病。更重要的是，血管生物学的进步促进了许多潜在的新疗法和预防策略的发展，以及生物工程装置和工程替代器官。然而，尽管我们对可溶性因子、细胞间相互作用、细胞外基质和微环境在血管发育、功能和病理学中的作用的理解取得了许多进展，但基础科学的主要方面仍知之甚少，重大的转化机会有待开发。研究人员已经认识到，可溶性调节因子、细胞间相互作用、细胞外基质和机械力共同作用于细胞， 调节关键信号通路，以确定心血管生理和病理。此外，开发这些环境监管投入的综合理解是开发再生医学方法和血管组织工程产品用于临床的关键。这个独特的计划将结合联合收割机两个研讨会，一个在血管系统的信号，第二个在细胞外基质的生物学和工程。它包括具体的翻译课程和专门为学员准备的会前会议。我们的目标是 为血管生物学、再生医学和生物工程这些互补领域的基础和临床研究人员提供一个互动的论坛，并为促进学员的教育和职业生涯提供一个极好的论坛。研讨会将是跨学科的，使生物学和工程学的研究人员能够聚集在一起，共同关注心血管疾病和再生的重要问题。该计划的特点是在包括血管形态发生，生长因子信号传导，机械转导，基质重塑和修复，基质遗传学和发育，干细胞生物学和组织工程等领域的前沿研究的介绍。我们相信，这些主题与NHLBI的使命高度相关，以促进我们的理解和开发新的工具来治疗疾病。在此申请中，我们要求资金部分支持这一跨学科的国际会议，该会议将汇集来自学术和私营部门的研究人员，博士后研究员和来自不同研究领域的研究生，为期四年。 进行了激烈的讨论和研究。会议将于2015年10月18日至22日在马萨诸塞州海恩尼斯科德角海恩尼斯度假村和会议中心举行。

 DESCRIPTION (provided by applicant): NAVBO Workshops at Vascular Biology 2015 October 18-22, 2015 Resort and Conference Center at Hyannis, Massachusetts. Principal Investigators: Martin Schwartz and Marsha Rolle. Vascular biology has evolved over the past decade as a major cross-disciplinary field of study which impacts a wide number of major human diseases beyond the more "traditional" vessel wall pathologies, such as atherosclerosis and hypertension. Today, vascular biology also contributes to our understanding of diabetes, metabolic syndrome, chronic kidney disease, neurological disorders, stroke, hematological disorders, cancer and various immunological diseases. More importantly, advances in vascular biology have contributed to the development of many potential new therapies and preventive strategies, in addition to bioengineered devices and engineered replacement organs. However, despite many advances in our understanding of the roles of both soluble factors, cell-cell interactions, the extracellular matrix and microenvironment in vascular development, function and pathology, major aspects of the basic science are poorly understood and major translational opportunities await exploitation. Researchers have come to understand that the soluble regulatory factors, cell-cell interactions, extracellular matrix and mechanical forces collectively regulate key signaling pathways to determine cardiovascular physiology and pathology. Furthermore, developing an integrated understanding of these environmental regulatory inputs is critical for developing regenerative medicine approaches and vascular tissue engineered products for clinical use. This unique program will combine two workshops, one on signaling in the vascular system, the second on the biology and engineering of the extracellular matrix. It includes specific translational sessions and a pre-meeting specifically for trainees. Our aim is to provide a forum for basic and clinical researchers in these complementary areas of vascular biology, regenerative medicine, and bioengineering to interact, and to provide a superb forum for furthering the education and careers of trainees. The workshops will be interdisciplinary, allowing researchers in biology and engineering to come together in a common focus to address important issues in cardiovascular disease and regeneration. The program is characterized by the presentation of cutting edge research in areas including vascular morphogenesis, growth factor signaling, mechanotransduction, matrix remodeling and repair, matrix genetics and development, stem cell biology, and tissue engineering. We believe these topics are highly relevant to the NHLBI's mission to further our understanding and develop new tools to treat disease. In this application we request funds to partially support this interdisciplinary, international conference which will serve to bring together investigators from the academic and private sectors, post-doctoral fellows, and graduate students from diverse fields of study for four days of intense discussion and study. The conference will be held at the Resort and Conference Center at Hyannis on Cape Cod in Hyannis, Massachusetts from October 18-22, 2015.