CORE B: METABOLIC AND MOLECULAR PHYSIOLOGY CORE

NIH-支持集中专业知识、工具和设施的努力，以促进全面 对基因工程小鼠、FISS和细胞的评估提高了我们对功能的理解 基因组学和疾病病理生物学。代谢和分子生理学核心(MMPC)提供 加州大学洛杉矶分校、加州大学圣地亚哥分校、雪松-西奈大学和索尔克研究所的调查人员以一系列最先进和低成本的 分子和生理分析不容易从NAfional表型中心获得。这个 MMPC分为四个子核：A)胰岛素敏感性和代谢，B)氧化代谢和 线粒体生物学，C)脂质图谱-脂质组学，以及D)炎症性信号转导，每个亚核心提供 广泛培训和咨询各种主题，从实验设计到数据解释和 积分学。具体地说，MMPC提供评估服务：移动、进食行为、间接 量热、身体组成、葡萄糖/胰岛素耐量、胰岛素分泌、底物代谢和氧化 能力，线粒体功能，循环和裂解脂质(脂质组学)，循环激素/脂肪因子/ 细胞因子和糖尿病并发症。MMPC维护着一个裂隙生物库以及一个全面的 大量表型技术和表型结果的标准方案数据库 各种各样的基因工程小鼠。MMPC领导层包括来自该领域的顶级调查人员 核受体生物学、脂代谢、炎症、脂肪细胞和骨骼肌生物学 包括：Peter Tontonoz，Andrea Hevener，Karen Reue，Rajendra Tangirala，Edward Dennis，Oswald 昆伯格。MMPC的优势包括其全面和互补的专业知识 领导力以及在生产力和高影响力科学宣传方面的杰出记录。这个 MMPC团队的五种协作精神营造了一个合作的环境，支持了协调良好的服务 与其他刚果民主共和国核心和机构资源合作。MMPC的中心目标是推动科学 使DRC能够成为前沿代谢分析的成员，以提高整体研究质量 加强了从细胞、胚胎、老鼠到人的研究思路的转换。

NIH-inifiated efforts to centralize expertise, instrumentafion, and facilifies to promote comprehensive evaluafion of genefically engineered mice, fissues and cells has improved our understanding of funcfional genomics and disease pathobiology. The Metabolic and Molecular Physiology Core (MMPC) provides investigators at UCLA, UCSD, Cedars-Sinai, and the Salk Institute with a series of state-of-the-art and costeffecfive molecular and physiological assays not readily available from nafional phenotyping centers. The MMPC is divided into four sub-cores: A) Insulin sensitivity and metabolism, B) Oxidative metabolism and mitochondrial biology, C) LIPID MAPS-lipidomics, and D) Inflammatory siganling, and each sub-core offers extensive training and consultafion on a variety of topics from experimental design to data interpretafion and integrafion. Specifically, the MMPC provides services to assess: movement, feeding behavior, indirect calorimetry, body composifion, glucose/insulin tolerance, insulin acfion, substrate metabolism and oxidative capacity, mitochondrial funcfion, circulafing and fissue lipids (lipidomics), circulafing hormones / adipokines / cytokines, and diabetes complicafions. The MMPC maintains a fissue bio-bank as well as a comprehensive database of standard protocols for a vast number of phenotyping techniques, and phenotypic outcomes for a wide variety of genefically engineered mice. The MMPC leadership includes top investigators from the fields of nuclear receptor biology, lipid metabolism, inflammafion, and adipocyte and skeletal muscle biology including: Peter Tontonoz, Andrea Hevener, Karen Reue, Rajendra Tangirala, Edward Dennis, Oswald Quehenberger. Strengths of the MMPC include the well-rounded and complementary expertise of its leadership and the excepfional track record of producfivity and high impact scientific publicafions. The collaborafive spirit ofthe MMPC team fosters a collegial environment and supports service well-coordinated with other DRC cores and institufional resources. The central goal ofthe MMPC is to advance the scientific capabilifies ofthe DRC membership in leading-edge metabolic analysis to improve overall research quality with enhanced translafiori of research ideas from cell, fissue and mouse to man.