Maternal Diabetes during Pregnancy and Neurodevelopment in the Offspring

 描述(由申请人提供)：这项建议建立在候选人之前使用丹麦民事登记系统和丹麦医学登记系统对不良产前暴露进行的八年研究的基础上，以及对后代的结果。通过与丹麦同事的现有合作，候选人获得了在这些独特的、大规模的、全国性的登记方面的机会和丰富的经验。她现在建议利用这些资源进行迄今为止规模最大、最全面的研究，以检查产妇糖尿病与一系列神经发育结果之间的关系，这些结果包括认知、行为、注意力和运动技能的标志。这项申请提出了一系列全国性的人口队列研究，这些研究将利用丹麦民事登记系统和丹麦的医疗登记。它有一个独特的优势，它还纳入了一个先前建立的非常大的队列，该队列嵌套在丹麦的总人口中，除了家庭、环境和职业暴露外，还包含广泛的产妇人口史；这将为关于胎儿环境中共同逆境的研究提供信息。此外，这项研究的另一个独特优势是能够评估同一人群队列中的一系列神经发育结果，最大限度地减少许多偏见的来源，并有助于解释这些发现。这一指导研究科学家发展奖将在加州大学洛杉矶分校流行病学系、奥胡斯大学和加州大学洛杉矶分校自闭症研究和治疗中心(CART)之间强大的持续合作关系的背景下进行。该应用程序将提供神经行为遗传学方面的培训，以便应聘者能够建立与分析来自可用于北欧生物库研究的大型存储库的数据相兼容的技能集，并在理解神经发育结果的胎儿编程方面获得深入的了解。比亚特·里茨博士和乔恩·奥尔森博士已经同意通过K99过程指导候选人。Dan Geschind博士将监督候选人在神经行为遗传学方面的培训，Diana Schendel博士将提供该项目的科学和技术指导，Tania Esakoff博士将向该项目提供她在管理妊娠期糖尿病方面的临床经验。这份申请的内容提供了一种策略来定位候选人，使她能够成功地进入终身教授跟踪职位，并获得必要的经验来走向独立和追求R01提案。

 DESCRIPTION (provided by applicant): This proposal builds on eight years of the candidate's previously conducted research on adverse prenatal exposures using the Danish Civil Registration System and Danish medical registers, and outcomes in the offspring. Through existing collaborations with Danish colleagues, the candidate has gained access and extensive experience with these unique, large-scale, nationwide registries. She now proposes to apply these resources to conduct the largest and most comprehensive study to date to examine the relationship between maternal diabetes and an array of neurodevelopmental outcomes that include markers of cognition, behavior, attention and motor skills. This application proposes a series of nationwide population cohort studies that will utilize the Danish Civil Registration System and Danish medical registers. It has the unique advantage of also incorporating a very large previously established cohort that is nested in the total population of Denmark and contains extensive maternal demographic histories in addition to household, environmental, and occupational exposures; this will inform the study on co-adversities in the fetal environment. Furthermore, another unique advantage of this study is the ability to asses an array of neurodevelopmental outcomes in the same population cohort, minimizing many sources of bias, and aiding the interpretation of these findings. This Mentored Research Scientist Development Award will be pursued within the context of a strong ongoing collaborative relationship between the UCLA Department of Epidemiology, Aarhus University and the UCLA Center for Autism Research and Treatment (CART). This application will provide training in neurobehavioral genetics so that the candidate can build a skillset compatible with analyzing data from large repositories available for research in the Nordic biobanks, and obtain depth in understanding of fetal programming of neurodevelopmental outcomes. Drs. Beate Ritz and Jorn Olsen have agreed to mentor the candidate through the K99 process. Dr. Dan Geschwind will oversee the candidate's training in neurobehavioral genetics, Dr. Diana Schendel will provide scientific and technical guidance on the project and Dr. Tania Esakoff will inform the project with her clinical experience in managing diabetes in pregnancy. The contents of this application provide a strategy to position the candidate such that she can launch successfully into a tenured professor track position, and gain the necessary experience to move towards independence and pursue R01 proposals.