Cellular and molecular foundations of biomedical science

描述（由申请人提供）：这项关于“生物医学科学的细胞和分子基础”的培训资助提案是对11年前开始的成功计划的更新。它旨在培养研究生在生物医学科学的广泛基础，为他们提供工具，以了解现代生物学和健康的重要问题。这最初是通过核心课程模块在第一年完成的，涵盖遗传学，分子生物学，结构生物学，生物物理学，细胞生物学和基因组学和系统生物学。学生遵循这一点，在他们感兴趣的特定领域的选修课。该计划是基于生物科学系，但已扩大到包括从哥伦比亚的内科医生和外科医生学院以及在化学系教师建立教师。学生在多达三个实验室进行轮换，并可以与该计划的55名教师中的任何一名进行论文工作，其中大约一半分别在医学院和主校区。这为学生在优秀实验室的培训提供了更多的机会，并促进了哥伦比亚医学院和主校区师生之间的合作。教师工作在广泛的领域，包括结构生物学，分子生物学，微生物学，遗传学，生物信息学和系统生物学，发育生物学和神经生物学。实验系统也很广泛，包括细菌、酵母、果蝇、C.线虫、青蛙和老鼠。也使用人类组织培养系统，并且大多数系统考虑与人类健康和生理学相关的问题。每年要求10名研究生受训，以支持5名学生，每两年，通常在他们的第三和第四年。这将资助我们目前69名符合培训补助金条件的学生的14.5%。我们计划中最好的学生将被选中由这笔赠款资助。这将取决于他们在核心课程和其他课程中的表现，他们的轮换和论文赞助商的建议，以及赠款指导委员会审查的简短研究提案。哥伦比亚大学的教师和研究设施的资格是杰出的，并为学生提供了一个极好的培训环境。学生的优秀出版物的记录也证明了这一计划的成功。

DESCRIPTION (provided by applicant): This training grant proposal on the "The cellular and molecular foundations of biomedical sciences" is a renewal of a successful program started eleven years ago. It seeks to train graduate students in the broad fundamentals of biomedical sciences to provide them with the tools to understand important problems in modern biology and health. This is accomplished initially through Core course modules in the first year covering Genetics, Molecular Biology, Structural Biology, Biophysics, Cell Biology and Genomics and Systems Biology. Students follow this with electives in specific fields of their interest. The program is based in the Department of Biological Sciences, but has been expanded to include established faculty from Columbia's College of Physicians and Surgeons as well as faculty in the Department of Chemistry. Students undertake rotations in up to three laboratories and can do their thesis work with any of the 55 faculty in the program, roughly half of which are on the Medical School and Main campuses, respectively. This has provided expanded opportunities for training of the students in outstanding laboratories and has fostered collaboration between faculty and students at Columbia's Medical School and main campuses. The faculty work in a broad range of fields including structural biology, molecular biology, microbiology, genetics, bioinformatics and systems biology, developmental biology and neurobiology. Experimental systems are also broad including bacteria, yeast, drosophila, C. elegans, frogs and mice. Human tissue culture systems are also utilized and most systems consider problems relevant to human health and physiology. Ten graduate student traineeships are requested per year to support five students for two years each, usually in their third and fourth years. This will fund 14.5% of our current training grant eligible student pool of 69. The best students in our program will be chosen to be funded by this grant. This will be determined by their performance in the Core and other courses, recommendations from their rotation and thesis sponsors, and a short research proposal reviewed by the grant's steering committee. The qualifications of the faculty and the research facilities at Columbia are outstanding and provide a superb training environment for the students. The record of outstanding publications by the students also demonstrates the success of this program.