ASBMR Three Year Symposia

美国骨与矿物研究学会(ASBMR)是世界上最大的专业、科学和 医学会成立的目的是将临床和实验室科学家聚集在一起，他们参与了 研究骨骼和矿物质新陈代谢，有举办年度专题会议的成功历史。 自2002年以来，由美国国立卫生研究院R13年度拨款资助。此申请寻求为三年R13赠款提供资金，以 通过专注于三个具体的科学研究领域推进骨骼疾病领域：1)骨骼疾病 基因组学(“骨骼组学--将基因组发现转化为临床应用”)；2)骨骼脆弱性 (“骨骼脆性的当前概念：从细胞到替代物”)；3)骨骼对 骨关节炎的病理生理学和临床表现(“骨骼对关节退行性变的贡献和 骨关节炎“)。这三个领域涵盖了一系列主题，这些主题共同构成了 骨骼疾病的临床发病率和死亡率。本R13的总体目标是进一步刺激 通过汇集最好的技术来改善骨骼疾病患者护理的进展 将与联合国儿童基金会年度会议同时举行的三个专题讨论会中的每一个的研究人员 ASBMR.三个专题讨论会的每一个都将回顾每个主题领域的最新进展，与 与会者，并促进年轻研究人员和知名研究人员之间的互动。对于三者中的每一者 研讨会，与会者将被鼓励参加后续的ASBMR年会，以获得更多 与骨骼研究人员互动的机会。所有三年的议程都是由一个 组委会，头两年有忠实的演讲者。议程包括既定的和 年轻的调查人员、男性、女性和代表不足的少数族裔发言者。在每次会议结束时，一个 计划在晚宴上让年轻的调查员和更资深的调查员直接互动。 会议上的发言人。2016年，该研讨会将评估基因组学领域的最新贡献 到了解骨骼疾病的机制，从基本的分子生物学到动物模型 和双向翻译到人类，特别是在精准医学和靶向的范围内 治疗。2017年的研讨会将讨论骨骼潜在机制的最新研究 评估骨折风险的脆弱性和最先进的方法。此外，新的数据支持使用 将讨论骨折的替代标记物。2018年研讨会将促进基础、 骨骼和骨关节炎研究中的翻译和临床研究人员，重点关注最新数据 出现在关节内的软骨-骨结构和生理上。

The American Society for Bone and Mineral Research (ASBMR), the largest professional, scientific and medical society established to bring together clinical and laboratory-based scientists who are involved in the study of bone and mineral metabolism, has had a successful history of conducting annual topical meetings funded by single year NIH R13 grants since 2002. This application seeks funding for a three year R13 grant to advance the field of skeletal diseases by focusing on three specific areas of scientific research: 1) skeletal genomics (“Bone-omics–Translating Genomic Discoveries into Clinical Applications”); 2) bone fragility (“Current Concepts in Bone Fragility: From Cells to Surrogates”); 3) skeletal contributions to the pathophysiology and clinical manifestations of osteoarthritis (“Skeletal Contributions to Joint Degeneration and Osteoarthritis”). These three areas cover a range of topics that collectively contribute to a majority of the clinical morbidity and mortality of skeletal disease. The overall objective of this R13 is to stimulate further advances that will result in improved patient care for skeletal diseases by bringing together the best researchers for each of the three symposia that will be held in conjunction with the annual meetings of the ASBMR. Each of the three symposia will review the state of the art in each topic area, exchanging ideas with attendees, and stimulating the interaction between young and established researchers. For each of the three symposia, attendees will be encouraged to attend the subsequent ASBMR Annual Meetings for additional opportunities to interact with bone researchers. Agendas for all three years have been developed by an organizing committee with committed speakers for the first two years. The agendas include established and young investigators, men, women and underrepresented minority speakers. At the end of each meeting, a “dine-around” evening is planned to allow direct interaction between young investigators and more senior speakers at the meeting. In 2016, the symposium will appraise the latest contributions of the field of genomics to the understanding of skeletal disease mechanisms, ranging from basic molecular biology to animal models and bidirectional translation to humans, particularly within the scope of precision medicine and targeted treatments. The 2017 symposium will discuss the latest research on the mechanisms underlying skeletal fragility and state-of-the-art methods to assess fracture risk. In addition, new data supporting the use of surrogate markers for fracture will be discussed. The 2018 symposium will promote interaction among basic, translational and clinical researchers in skeletal and osteoarthritis research, with a focus on recent data emerging on cartilage-bone structure and physiology within articulating joints.