Pilot and Exploratory Core
试点和探索核心
基本信息
- 批准号:10293913
- 负责人:
- 金额:$ 29.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdultAffectAgeAgingAnimal ModelApplications GrantsBehavior TherapyBiological MarkersBostonCapsicumCell AgingCellsDNA MethylationDataDevelopmentDoctor of PhilosophyElderlyEpigenetic ProcessExposure toFibroblastsFosteringFundingGenderGenerationsImpairmentInflammagingInflammationInflammatoryInfrastructureIntellectual PropertyInterdisciplinary StudyInterleukin-6Interstitial Lung DiseasesInterventionInvestigationLegal patentLife Cycle StagesLinkLungLung diseasesMentorshipMissionMuscle functionOrganOrgan TransplantationOutcomeOutcome StudyParticipantPatientsPeer ReviewPhenotypePhysical ExercisePhysical FunctionProteomicsProtocols documentationPsychosocial StressPublicationsPulmonary FibrosisRequest for ApplicationsResearchResearch PersonnelResearch Project GrantsResourcesRoleScienceScientific Advances and AccomplishmentsScientistSkeletal MuscleStressTestingTimeTranslational ResearchTransplantationbasecareerdosageearly life stressexercise capacityexercise interventionfollow-upfunctional declinehuman studyidiopathic pulmonary fibrosisimprovedinnovationinterstitiallung imagingmedical schoolspatient stratificationperipheral bloodpre-clinicalprogramspsychosocial stressorsrandomized trialresponsesafety and feasibilitysenescencetransgendertranslational approachtranslational pipeline
项目摘要
SUMMARY / ABSTRACT
The aim of the Boston Pepper OAIC is to support an interdisciplinary research program that fosters the
development of function promoting therapies (FPTs). Within the context of the OAIC's overall mission, the Pilot
and Exploratory Studies Core (PESC) will catalyze scientific advances in FPTs through funding of pilot and
exploratory studies, and provision of mentorship and infrastructural core support. The overall objective of the
PESC is to enable early stage investigator-initiated studies to acquire the pilot data needed to develop a
robust, well-funded, and productive translational research projects of FPTs. The primary objective of the PESC
in the context of this renewal is to build upon the science underlying our OAIC theme, while a secondary
objective is to help build the careers of scientists whose research is aligned with our theme. Aim 1 will
continue with our translational pipeline for early stage innovative and interdisciplinary research by providing
funding that leverages our Boston Pepper OAIC cores and infrastructure for the generation of proof-of-concept
preclinical data to expedite the development of FPTs, mechanistic studies for target identification or
hypotheses building by which FPTs exert effects on skeletal muscle and physical function; and pilot testing of
translational interventions or research protocols in human study participants or animal models for safety,
feasibility, or determination of optimal time course or dosage. Aim 2 will foster connectivity between PESC
investigators and OAIC resource cores. Aim 3 will catalyze pilot and exploratory projects into high quality peer-
reviewed publications, grant applications, and intellectual property/patents.
Our Boston Pepper OAIC Steering Commmitteee selected three innovative candidate projects for
consideration of PESC support in our renewal, from among a pool of 19 applications that were received in
response to a widely advertised request for applications (RFA). These three canddidate projects are well
aligned with the OAIC's mission of promoting the development of FPTs by mechanism elucidation, target
identification, proof-of-concept studies in model organisms, epidemiolgical investigation, and randomized trials,
and would benefit from the use of our resource cores. The three projects are founded on innovative
hypotheses of the role of cellular senescence in interstitial lung disease and suboptimal outcomes of
transplanted organs from older donors, as well as epigenetic mechanisms by which early life stress affects the
trajectory of aging among transgender people. PES-1 evaluates whether transplanting older organs initiates
the spread of senescent cells through senescence-associated secretory phenotype (SASP) linked
inflammatory programs that adversely influence physical function in older adults. PES-2 will examine the
role of senescence-associated biomarkers in improving the identification and prediction of early stage of
pulmonary fibrosis (PF) identified as interstitial lung abnormalities (ILA) based on pulmonary imaging. PES-3
will evaluate stress-driven acceleration of epigenetic age and inflammation in transgender adults.
摘要/摘要
波士顿胡椒OAIC的目标是支持一个跨学科的研究计划,以促进
功能促进疗法(FPTs)的发展。在审查办的总体任务范围内,飞行员
和探索性研究核心(PESC)将通过资助试点和
探索性研究,并提供指导和基础设施核心支持。《公约》的总体目标
PESC将使研究人员发起的早期研究能够获得开发
雄厚、资金充足和富有成效的烟草控制框架下的翻译研究项目。PESC的首要目标
在这次更新的背景下,是建立在我们伊斯兰会议组织主题的科学基础上,而次要的
目标是帮助那些研究与我们的主题相一致的科学家建立职业生涯。目标1将
继续为早期创新和跨学科研究提供翻译渠道,通过提供
利用我们的Boston Pepper OAIC核心和基础设施生成概念验证的资金
临床前数据,以加快FPTS的开发,靶标识别的机制研究或
建立FPT对骨骼肌和身体功能产生影响的假设;以及初步测试
人类研究参与者或动物模型中的转译干预或研究方案以确保安全,
可行性,或最佳时间进程或剂量的确定。AIM 2将促进PESC之间的连接
调查员和伊斯兰会议组织资源核心。目标3将催化试点和探索性项目成为高质量的同行-
审查出版物、授权申请和知识产权/专利。
我们的波士顿胡椒OAIC指导委员会选出了三个创新的候选项目
在我们的续签中考虑PESC的支持,从#年收到的19份申请中
响应广为宣传的应用程序请求(RFA)。这三个坦率的项目都很好
与OAIC通过阐明机制促进FPTS发展的使命保持一致,目标
鉴定、模式生物的概念验证研究、流行病学调查和随机试验,
并将从我们的资源核心的使用中受益。这三个项目建立在创新的基础上
细胞衰老在间质性肺疾病中作用的假说和次优转归
来自老年捐赠者的移植器官,以及早期生活应激影响的表观遗传学机制
变性人的老龄化轨迹。PES-1评估移植较老的器官是否启动
衰老细胞通过衰老相关分泌表型(SASP)的传播
对老年人身体功能产生不利影响的炎症性项目。PES-2将检查
衰老相关生物标志物在提高老年痴呆早期识别和预测中的作用
肺纤维化(PF)是基于肺部影像的间质性肺异常(ILA)。PES-3
将评估压力驱动的变性人表观遗传年龄和炎症的加速。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DOUGLAS P. KIEL其他文献
DOUGLAS P. KIEL的其他文献
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{{ truncateString('DOUGLAS P. KIEL', 18)}}的其他基金
Determinants and Outcomes of Age-related Muscle Loss
年龄相关性肌肉损失的决定因素和结果
- 批准号:
10665049 - 财政年份:2021
- 资助金额:
$ 29.25万 - 项目类别:
Bone Microarchitecture: The Framingham Osteoporosis Study
骨微结构:弗雷明汉骨质疏松症研究
- 批准号:
8631420 - 财政年份:2012
- 资助金额:
$ 29.25万 - 项目类别:
Targeted Sequencing of 3 Loci Associated with BMD in the Framingham Osteoporosis
Framingham 骨质疏松症中与 BMD 相关的 3 个位点的靶向测序
- 批准号:
8118736 - 财政年份:2011
- 资助金额:
$ 29.25万 - 项目类别:
Targeted Sequencing of 3 Loci Associated with BMD in the Framingham Osteoporosis
Framingham 骨质疏松症中与 BMD 相关的 3 个位点的靶向测序
- 批准号:
8254457 - 财政年份:2011
- 资助金额:
$ 29.25万 - 项目类别:
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