Pilot and Exploratory Core
试点和探索核心
基本信息
- 批准号:10293913
- 负责人:
- 金额:$ 29.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdultAffectAgeAgingAnimal ModelApplications GrantsBehavior TherapyBiological MarkersBostonCapsicumCell AgingCellsDNA MethylationDataDevelopmentDoctor of PhilosophyElderlyEpigenetic ProcessExposure toFibroblastsFosteringFundingGenderGenerationsImpairmentInflammagingInflammationInflammatoryInfrastructureIntellectual PropertyInterdisciplinary StudyInterleukin-6Interstitial Lung DiseasesInterventionInvestigationLegal patentLife Cycle StagesLinkLungLung diseasesMentorshipMissionMuscle functionOrganOrgan TransplantationOutcomeOutcome StudyParticipantPatientsPeer ReviewPhenotypePhysical ExercisePhysical FunctionProteomicsProtocols documentationPsychosocial StressPublicationsPulmonary FibrosisRequest for ApplicationsResearchResearch PersonnelResearch Project GrantsResourcesRoleScienceScientific Advances and AccomplishmentsScientistSkeletal MuscleStressTestingTimeTranslational ResearchTransplantationbasecareerdosageearly life stressexercise capacityexercise interventionfollow-upfunctional declinehuman studyidiopathic pulmonary fibrosisimprovedinnovationinterstitiallung imagingmedical schoolspatient stratificationperipheral bloodpre-clinicalprogramspsychosocial stressorsrandomized trialresponsesafety and feasibilitysenescencetransgendertranslational approachtranslational pipeline
项目摘要
SUMMARY / ABSTRACT
The aim of the Boston Pepper OAIC is to support an interdisciplinary research program that fosters the
development of function promoting therapies (FPTs). Within the context of the OAIC's overall mission, the Pilot
and Exploratory Studies Core (PESC) will catalyze scientific advances in FPTs through funding of pilot and
exploratory studies, and provision of mentorship and infrastructural core support. The overall objective of the
PESC is to enable early stage investigator-initiated studies to acquire the pilot data needed to develop a
robust, well-funded, and productive translational research projects of FPTs. The primary objective of the PESC
in the context of this renewal is to build upon the science underlying our OAIC theme, while a secondary
objective is to help build the careers of scientists whose research is aligned with our theme. Aim 1 will
continue with our translational pipeline for early stage innovative and interdisciplinary research by providing
funding that leverages our Boston Pepper OAIC cores and infrastructure for the generation of proof-of-concept
preclinical data to expedite the development of FPTs, mechanistic studies for target identification or
hypotheses building by which FPTs exert effects on skeletal muscle and physical function; and pilot testing of
translational interventions or research protocols in human study participants or animal models for safety,
feasibility, or determination of optimal time course or dosage. Aim 2 will foster connectivity between PESC
investigators and OAIC resource cores. Aim 3 will catalyze pilot and exploratory projects into high quality peer-
reviewed publications, grant applications, and intellectual property/patents.
Our Boston Pepper OAIC Steering Commmitteee selected three innovative candidate projects for
consideration of PESC support in our renewal, from among a pool of 19 applications that were received in
response to a widely advertised request for applications (RFA). These three canddidate projects are well
aligned with the OAIC's mission of promoting the development of FPTs by mechanism elucidation, target
identification, proof-of-concept studies in model organisms, epidemiolgical investigation, and randomized trials,
and would benefit from the use of our resource cores. The three projects are founded on innovative
hypotheses of the role of cellular senescence in interstitial lung disease and suboptimal outcomes of
transplanted organs from older donors, as well as epigenetic mechanisms by which early life stress affects the
trajectory of aging among transgender people. PES-1 evaluates whether transplanting older organs initiates
the spread of senescent cells through senescence-associated secretory phenotype (SASP) linked
inflammatory programs that adversely influence physical function in older adults. PES-2 will examine the
role of senescence-associated biomarkers in improving the identification and prediction of early stage of
pulmonary fibrosis (PF) identified as interstitial lung abnormalities (ILA) based on pulmonary imaging. PES-3
will evaluate stress-driven acceleration of epigenetic age and inflammation in transgender adults.
总结/摘要
波士顿胡椒OAIC的目的是支持一个跨学科的研究计划,促进
功能促进疗法(FPT)。在审计和调查办公室的总体使命范围内,
和探索性研究核心(PESC)将通过资助试点和
探索性研究,并提供指导和基础设施的核心支持。的总体目标
PESC是为了使早期阶段的制冷剂启动的研究,以获得试点数据所需的发展,
强大的,资金充足的,富有成效的FPT转化研究项目。PESC的主要目标
在这种更新的背景下,是建立在我们OAIC主题的科学基础上,而第二个
我们的目标是帮助那些研究与我们的主题相一致的科学家建立职业生涯。目标1将
继续我们的翻译管道为早期阶段的创新和跨学科的研究,提供
利用我们的Boston Pepper OAIC核心和基础设施进行概念验证的资金
临床前数据,以加快FPT的开发,靶点鉴定的机制研究,或
FPT对骨骼肌和身体功能产生影响的假设建立;以及
在人类研究参与者或动物模型中的安全性转化干预或研究方案,
可行性,或确定最佳的时间进程或剂量。目标2将促进PESC之间的联系
调查员和审调处资源核心。目标3将促进试点和探索性项目成为高质量的同行项目,
审查出版物、资助申请和知识产权/专利。
我们的波士顿胡椒OAIC指导委员会选择了三个创新的候选项目,
考虑PESC的支持,在我们的更新,从19个申请,收到了在
对广泛宣传的应用程序请求(RFA)的响应。这三个canddidate项目很好
与OAIC通过机制阐明促进FPT发展的使命相一致,
鉴定、模式生物概念验证研究、流行病学调查和随机试验,
并将受益于我们的资源核心的使用。这三个项目是建立在创新
细胞衰老在间质性肺疾病中的作用的假说和
老年捐赠者的器官移植,以及早期生活压力影响器官移植的表观遗传机制。
跨性别人群的衰老轨迹。PES-1评估移植较旧的器官是否会引发
衰老细胞通过衰老相关分泌表型(SASP)扩散,
炎症程序对老年人的身体功能产生不利影响。PES-2将检查
衰老相关生物标志物在改善衰老早期阶段的识别和预测中的作用
肺纤维化(PF),根据肺成像确定为间质性肺异常(ILA)。PES-3
将评估压力驱动的表观遗传年龄加速和变性成年人的炎症。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DOUGLAS P. KIEL其他文献
DOUGLAS P. KIEL的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DOUGLAS P. KIEL', 18)}}的其他基金
Determinants and Outcomes of Age-related Muscle Loss
年龄相关性肌肉损失的决定因素和结果
- 批准号:
10665049 - 财政年份:2021
- 资助金额:
$ 29.25万 - 项目类别:
Bone Microarchitecture: The Framingham Osteoporosis Study
骨微结构:弗雷明汉骨质疏松症研究
- 批准号:
8631420 - 财政年份:2012
- 资助金额:
$ 29.25万 - 项目类别:
Targeted Sequencing of 3 Loci Associated with BMD in the Framingham Osteoporosis
Framingham 骨质疏松症中与 BMD 相关的 3 个位点的靶向测序
- 批准号:
8118736 - 财政年份:2011
- 资助金额:
$ 29.25万 - 项目类别:
Targeted Sequencing of 3 Loci Associated with BMD in the Framingham Osteoporosis
Framingham 骨质疏松症中与 BMD 相关的 3 个位点的靶向测序
- 批准号:
8254457 - 财政年份:2011
- 资助金额:
$ 29.25万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 29.25万 - 项目类别:
Research Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 29.25万 - 项目类别:
Standard Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 29.25万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 29.25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 29.25万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 29.25万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 29.25万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 29.25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 29.25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 29.25万 - 项目类别:
Grant-in-Aid for Scientific Research (C)