ShEEP Equipment Request for Magventure X100 fMRI-TMS System

 描述(由申请人提供)： 在过去的十年里，需要将外源性刺激大脑的技术与内源性大脑激活技术相结合。主要的方法是前者的经颅磁刺激和后者的功能磁共振成像。由于核磁共振设备提供的高磁场，这些技术相互隔离。由于安全问题以及与产生瞬变磁场(TMS的作用方法)相关的技术不兼容，无法在MRI扫描仪中使用TMS。然而，在过去的五年中，MagVenture开发了一种与MRI兼容的rTMS线圈系统，用于连接他们出色的X100 TMS刺激器系统。X100能够支持单脉冲、成对脉冲，现在正在进行实验测试，甚至可以重复TMS(RTMS)。科学家和治疗师可以使用rTMS来增加或降低皮质神经元的兴奋性，这取决于刺激的速度。因此，大脑的局部激活或去激活是不同的，研究人员有很短的机会(有效地10-20分钟)来探索神经可塑性。X100能够提供高达100赫兹的刺激，这比市场上的其他系统要大得多，并为研究人员提供了独特的皮质调制能力。TMS的工作原理是通过刺激线圈输送电流来瞬间改变磁场。MagVenture拥有当今市场上最强大的激励线圈系列，其中包括与磁共振成像环境兼容的唯一商用TMS线圈。这项技术的应用在本呈件的研究计划中有详细说明，并取决于个别调查人员的需要。因此，X100 TMS-fMRI系统为众多研究人员提供了一种多功能工具，以解决他们的研究计划中感兴趣的问题。它是市场上唯一能够满足这些需求的产品。目前的申请代表了6名退伍军人管理局附属研究人员对X100系统的使用感兴趣。主要成员包括：Keith McGregor博士、Bruce Crosson博士和Andy Butler博士。辅修组包括：Paul Garcia，医学博士，Joe Nocera，博士，Catherin Buetefisch，医学，博士和Michael Borich，博士。这些用户代表了一个强大的研究人员核心，他们有兴趣使用X100通过提高我们对皮质网络的理解来改善为退伍军人提供的医疗服务。

 DESCRIPTION (provided by applicant): Over the past ten years, there has been a need to integrate technologies for exogenous stimulation of the brain with endogenous activation of the brain. The predominant methodologies for these are for the former transcranial magnetic stimulation and the latter functional magnetic resonance imaging. These technologies have been isolated from one another because of the high-magnetic field presented by the MRI device. Using TMS in the MRI scanner could not be done due to safety concerns as well as technical incompatibilities relating to the generation of a transient magnetic field (the method of action of TMS). However, in the past five years, MagVenture has developed an MRI compatible rTMS coil system for attachment to their excellent X100 TMS stimulator system. The X100 is capable of single pulse, paired pulse and, now under experimental testing, even repetitive TMS (rTMS). rTMS can be used by scientists and therapists to increase or decrease the excitability of cortical neurons depending on the rate of stimulation. As a result, regional activation or deactivation of the brain is altere and investigators have a short window of opportunity (effectively 10-20 minutes) to probe neuroplasticity. The X100 is capable of up to 100Hz of stimulation which is much greater than other systems on the market and gives investigators a unique capability for cortical modulation. TMS works by transiently changing the magnetic field by delivering current through a stimulating coil. MagVenture has the strongest array of stimulating coils on the market today including the only commercially available TMS coil compatible with an MRI environment. The applications of this technology are detailed in the research plans of this submission and are dependent on the needs of the individual investigators. As such, the X100 TMS-fMRI system provides a versatile tool for numerous researchers to approach questions of interest respective of their research programs. It is the only product on the market than can fulfill these needs. The current application represent interest in the use of the X100 system by 6 VA-affiliated researchers. The Major Group includes: Keith McGregor, PhD; Bruce Crosson, PhD, and Andy Butler, PhD-PT, MBA. The Minor group includes: Paul Garcia, MD., PhD; Joe Nocera, PhD, Catherin Buetefisch, MD, PhD and Michael Borich, PhD. These users represent a strong core of researchers with interests in using the X100 to improve healthcare delivery to Veteran's by improving our understanding of cortical networks.