Affective and Neurocognitive Dimensions across Eating Disorder Psychopathology

描述（由申请人提供）：本申请为指导的以患者为导向的研究职业发展奖提出了培训和研究，旨在为候选人提供一个基础，以建立一个成功的职业生涯，作为一个独立的调查员，在生物行为研究方面具有神经认知和负面情感的专业知识，这些知识是饮食失调精神病理学的基础。该应用程序的培训和研究目标与NIMH战略计划的战略1.4一致，以开发基于行为和神经生物学维度的精神病理学分类研究的新方法。候选人寻求三个领域的高级培训：（1）多维和多方法方法研究和分类精神病理学，（2）神经认知和相关任务，和（3）神经生物学和功能性磁共振成像（fMRI）的使用研究理论上相关的神经回路饮食失调。培训将由一个由导师和顾问组成的跨学科小组指导，课程作业、讲习班）和非正式（例如，指导阅读、指导会议）活动。该研究计划提出了两项研究，以阐明神经认知和情感变量在进食障碍精神病理学中的作用。在第一项研究中，神经认知的维度（例如，反应抑制，决策）和消极情感（例如，情绪反应、痛苦耐受性）将在从社区和临床环境中招募的80名妇女的广泛样本中进行检查，这些妇女表现出一系列临床显著形式的进食障碍精神病理学。参与者将完成半结构化访谈，自我报告的措施，和行为任务，以检查在何种程度上的神经认知和情感方面与认知和行为表现的进食障碍精神病理学。在第二项研究中，24名参与者的样本包括临床显著的进食障碍精神病理学的女性，包括暴饮暴食（n=12）和非进食障碍对照（n=12），将完成fMRI协议评估静息状态活动和任务诱发活动与反应抑制和负性情感刺激的处理。本研究将提供与暴食为特征的进食障碍表现中的抑制控制和情感功能相关的神经回路数据。重要的是，这些结果可以为改进现有饮食失调治疗方法和开发针对正在调查的生物行为变量的新干预措施提供信息。总之，本申请中提出的高级培训目标和研究将促进候选人成功成为以患者为导向的研究中的独立调查员，在饮食失调领域具有特别的专业知识，以及与饮食失调精神病理学基础的生物行为功能维度研究的新计划相一致的相关方法和统计方法。

DESCRIPTION (provided by applicant): This application for a Mentored Patient-Oriented Research Career Development Award proposes training and research designed to provide the candidate with a foundation to establish a successful career as an independent investigator with expertise in biobehavioral research on dimensions of neurocognition and negative affectivity that underlie eating disorder psychopathology. The training and research goals of this application are consistent with Strategy 1.4 of the NIMH Strategic Plan to develop new ways of classifying psychopathology for research based on behavioral and neurobiological dimensions. The candidate seeks advanced training in three areas: (1) dimensional and multi-method approaches to studying and classifying psychopathology, (2) neurocognition and associated tasks, and (3) neurobiology and the use of functional magnetic resonance imaging (fMRI) to study theoretically relevant neurocircuitry in eating disorders. Training will be guided by an interdisciplinary team of mentors and consultants and will involve formal (e.g., coursework, workshops) and informal (e.g., directed readings, mentoring meetings) activities across the funding period. The research plan proposes two studies to elucidate the role of neurocognitive and affective variables in eating disorder psychopathology. In the first study, dimensions of neurocognition (e.g., response inhibition, decision making) and negative affectivity (e.g., emotional reactivity, distress tolerance) will be examined in a broad sample of 80 women recruited from community and clinical settings who present with a range of clinically significant forms of eating disorder psychopathology. Participants will complete semi-structured interviews, self-report measures, and behavioral tasks to examine the extent to which the neurocognitive and affective dimensions are associated with cognitive and behavioral manifestations of eating disorder psychopathology. In the second study, a sample of 24 participants comprised of women with clinically significant eating disorder psychopathology involving binge eating (n=12) and non-eating disorder controls (n=12) will complete an fMRI protocol assessing resting-state activity and task-evoked activity associated with response inhibition and processing of negative affective stimuli. This study will provide data on neurocircuitry associated with inhibitory contro and affective functioning in eating disorder presentations characterized by binge eating. Importantly, these results may inform efforts to refine existing eating disorder treatments and develop new interventions targeting the biobehavioral variables under investigation. In sum, the advanced training goals and research proposed in this application will facilitate the candidate's success in becoming an independent investigator in patient-oriented research, with particular expertise in the field of eating disorders, as well as associated methodological and statistical approaches consistent with a novel program of research on dimensions of biobehavioral functioning underlying eating disorder psychopathology.