Computational Core

摘要-计算核心 拟议的计算核心将提供理论和建模动手的专业知识，所有的项目， 中心。在任何时候，都会有至少一个核心的博士后或研究生积极对接 每个项目。项目PI和建模核心之间的定期月度会议将有助于澄清 每个项目的实验和建模目标，以增强集成。实验意义 和模拟结果将在这些会议上讨论，未来的实验和模拟工作将 计划好了计算核心还将积极开发用户友好的软件包，用于辅助数据 收集，以及Matlab例程和软件运行模拟的非专家。教程 模型概念、模型结果和开发的软件也将在中心范围的务虚会上进行 作为中心研讨会一年两次。所有开发的软件包将提供给研究人员 在中心以及更大的社区。计算目标的目标是：（1）开发一个3D 用于模拟反应-扩散-平流同时进行的单细胞迁移的计算框架 复杂生化信号通路的方程式。(2)构建仿真计算平台 离散数量的相互作用的运动细胞。将关键物理参数和粗粒度 生物化学信号通路的建模。(3)从单个细胞的离散模型到3D连续体的桥梁 模拟多细胞群体迁移的算法。

Summary - Computational Core The proposed computational core will provide theory and modeling hands-on expertise to all of the projects in the Center. At any time, there will be at least one postdoc or graduate student of the Core actively interfacing with each project. Regular monthly meetings between project PIs and the modeling core will help to clarify the experimental and modeling objectives of each project for enhanced integration. Significance of experimental and modeling results will be discussed at these meetings, and future experiments and modeling work will be planned. The computational core will also actively develop user-friendly software packages for assisting data collection, as well as Matlab routines and software for running simulations by non-experts. Tutorials on modeling concepts, modeling results, and developed software will be conducted at center-wide retreats as well as center symposia twice a year. All of the developed software packages will be made available to researchers in the Center as well as the larger community. The aims of the computational aims are: (1) Develop a 3D computational framework for simulating single-cell migration simultaneously with reaction-diffusion-advection equations for complex biochemical signaling pathways. (2) Construct a computational platform for simulating discrete numbers of interacting motile cells. Incorporate key physical parameters as well as coarse-grained modeling of biochemical signaling pathways. (3) Bridge from discrete models of single cells to 3D continuum algorithms for simulating the migration of multicellular groups.