Circadian Rhythm in GI Health and Disease

 描述（由申请人提供）： 生物钟参与几乎所有的生理过程。同样，昼夜节律在调节我们消化系统的各种过程中也很重要，包括细胞增殖、免疫稳态、肠道通透性和微生物失衡。因此，昼夜节律的破坏（与现代生活方式相关的一个因素）与西方国家正在上升的各种GI相关病理有关，这并不奇怪。这些病症包括但不限于功能性GI疾病、炎性肠病、酒精性和非酒精性肝病、代谢紊乱、肥胖和胃肠（GI）癌（例如，结肠癌尽管越来越多的人认识到胃肠道健康和疾病的昼夜节律调节，但许多研究人员，包括基础科学家和临床研究人员，以及执业临床医生，都没有意识到这一主题对胃肠道健康和疾病的重要性。 预防和治疗各种胃肠道、肝脏、代谢和神经系统疾病。在这里，我们提出了一个关于“胃肠道健康和疾病的昼夜节律”的研讨会，这将是第一次，涵盖了昼夜节律障碍对各种消化道和酒精相关的病理学的影响，如肠道炎症，肝脏疾病，代谢综合征，胃肠道癌症以及脑肠道通路。此外，本次研讨会将为科学家，博士后研究员，培训研究员，临床医生和临床科学家提供一个高度动态和互动的环境，以讨论和了解昼夜节律在GI/肝脏和代谢/营养疾病中的作用。年轻的研究人员将被鼓励进入这一领域，多中心的合作将最终形成，以促进我们对消化系统生物钟的理解。

 DESCRIPTION (provided by applicant): Circadian clocks are involved in almost all physiologic processes. Similarly, circadian rhythms is shown to be important in regulating variety of processes in our digestive system, including cell proliferation, immune homeostasis, gut permeability and microbial imbalance. Therefore it is not surprising that disruption of circadian rhythm, a factor associated with modern life style, has been implicated in a variety of GI related pathologies that are on the rise in Western countries. These conditions include but are not limited to functional GI diseases, inflammatory bowel disease, alcoholic and non-alcoholic liver disease, metabolic disorders, obesity and gastrointestinal (GI) cancers (e.g., colon cancer. Despite the growing recognition of circadian regulation in GI health and disease, many investigators including basic scientists and clinical researchers, as well as practicing clinicians, are unaware of the importance of this topic for both prevention and treatment of variety of gastrointestinal, hepatic, metabolic and neurologic pathologies. Here we propose a symposium on "circadian rhythm in GI health and disease" which will, for the first time, cover the impact of circadian dysrhythmia on variety of digestive ad alcohol related pathologies such as gut inflammation, liver diseases, metabolic syndromes, GI cancers as well as brain-gut pathways. Also this symposium will provide scientists, post-doctoral fellows, fellows-in-training, clinicians, and clinician-scientists with a highly dynamic and interactive environment to discuss and learn about the role of circadian rhythms in GI/liver and metabolic/nutrition diseases. Young researchers will be encouraged to enter the field, and multi-central collaborations will form to, eventually, advance our understanding of circadian clock in our digestive system.