Effects of Training in Visuospatial Working Memory

描述（由申请人提供）：前额叶皮层（PFC）是大脑中对认知过程（如视觉工作记忆）至关重要的区域。几乎所有以前在前额叶皮层的工作记忆研究，特别是在动物模型中，都使用了在行为任务方面受过高度训练的受试者。很少有人知道这种训练的效果， 前额叶皮层以及原生工作记忆反应如何因训练范式而改变。提出的实验将研究前和后前额叶皮层分区的属性之前和之后掌握的视觉空间工作记忆任务，以确定在这些时间点的前额叶皮层的神经生理结构。同样，实验也将调查的属性传入的视觉空间刺激之前和之后的多刺激任务中的训练的工作记忆容量限制。这些实验的结果将提供有关大脑中视觉工作记忆处理的信息，并将提供有关神经系统疾病（如中风）以及注意力缺陷等情况下工作记忆训练策略的见解。 多动症

DESCRIPTION (provided by applicant): The prefrontal cortex (PFC) is an area of the brain essential for cognitive processes such as visual working memory. Nearly all previous working memory studies in the prefrontal cortex, especially in animal models, have used subjects that were highly trained in behavioral tasks. Very little is known about the effects of this training on the prefrontal cortex and how native working memory responses are altered due to the training paradigm. The experiments proposed will study the properties of the anterior and posterior prefrontal cortex divisions prior to and following mastery of visuospatial working memory tasks in order to determine the neurophysiological structure of the prefrontal cortex during these time points. Similarly, the experiments will also investigate the properties of the working memory capacity limit for incoming visuospatial stimuli prior to and following training in a multiple-stimulus task. The results from these experiments will provide information about the processing of visual working memory in the brain and will provide insights on working memory training strategies in neurological disorders such as stroke as well in conditions such as attention deficit hyperactivity disorder.