IGF::OT::IGF BLDG. 469- 2ND FLOOR REFURBISHMENT & INFRASTRUCTURE

469号楼二楼的翻新计划是为了巩固并提供适当的实验室空间，用于病理学和组织技术实验室、动物分子诊断实验室和高通量小鼠基因分型实验室，为NCI研究人员的动物研究活动提供科学支持服务。具体而言，病理和组织技术实验室协助动物研究设计，并提供成像和图像分析，激光捕获显微解剖，免疫组织化学，组织微阵列和病理评估。动物分子诊断实验室负责在腓特烈和贝塞斯达的国家传染病研究所经营的动物设施中对所有啮齿动物进行健康监测，并侧重于使用聚合酶链反应等分子测定法。高通量小鼠基因分型实验室为培育基因工程小鼠的研究人员提供基因分型服务，以识别具有特定感兴趣基因的小鼠，然后将其用于实验方案，并专注于使用自动分析，以便快速对大量动物进行基因分型。这些实验室的共同位置将允许这些小组共享设备/仪器，并跨不同学科交叉培训和共享工作人员，以提高效率和有效性。

The Building 469, second floor refurbishment is planned to consolidate and provide appropriate laboratory space for the Pathology and Histotechnology Laboratory, the Animal Molecular Diagnostic Laboratory and the High-Throughput Mouse Genotyping Laboratory which provide scientific support services for the animal-based research activities of NCI investigators. Specifically, the Pathology and Histotechnology Laboratory assists in animal study design and provides imaging and image analysis, laser capture micro-dissection, immunohistochemistry, tissue microarray and pathology evaluation. The Animal Molecular Diagnostic Laboratory is responsible for the health monitoring of all rodents at the NCI-operated animal facilities in Frederick and Bethesda and focusses on the use of molecular assays such as PCR. The High-Throughput Mouse Genotyping Laboratory providing genotyping services to investigators breeding genetically engineered mice to identify mice baring particular genes of interest, which are then used in experimental protocols and focusses on the use of automated assays so that high numbers of animals can be genotyped quickly. The co-location of these laboratories will allow these groups to share equipment/instrumentation and to cross-train and share staff across the different disciplines to enhance efficiencies and effectiveness.