GH12-004, S. Africa: GDD Public Health Research

描述（由申请人提供-逐字）： 疟疾病媒控制主要依靠使用化学杀虫剂。然而，目前在南非逐步消灭和根除疟疾的努力要求开发更多的控制工具，以补充现有的战略。 该项目的目的是评价南非境内三种互不相关的疟疾病媒控制技术。主要目标是： 1.确定昆虫不育技术在南非控制疟疾病媒的可行性。这个目标的具体目的是确定相对交配竞争力的不育实验室饲养的雄性阿拉伯按蚊蚊子相比，其肥沃的野生同行，以及测量的疟原虫感染性的照射女性相比，未照射的女性。 2.测试白色胡椒和胡椒碱（胡椒的主要成分）作为南方疟疾媒介幼虫杀灭剂 非洲 3.测试C8910对疟疾病媒物种的杀虫剂抗性和敏感菌株的驱避和杀虫特性。 .

DESCRIPTION (provided by the applicant - verbatim): Malaria vector control relies principally on the application of chemical insecticides. However, the current drive towards sequential elimination and eradication of malaria in South Africa requires that additional control tools be developed to complement existing strategies. The aim of this project is to evaluate three unrelated malaria vector control technologies within South Africa. The principal objectives are to: 1. Establish the feasibility of the sterile insect technique for malaria vector control in South Africa. The specific aim of this objective is to ascertain the relative mating competitiveness of sterile laboratory reared male Anopheles arabiensis mosquitoes compared to their fertile wild counterparts as well as to measure the Plasmodium infectivity of irradiated females compared to unirradiated females. 2. Test white pepper and piperine, a key constituent of pepper, as malaria vector larvicides in South Africa. 3. Test the repellent and insecticidal properties of C8910 against insecticide resistant and susceptible strains of malaria vector species. .