Console Upgrade for a 600 MHz NMR Spectrometer

 描述（由申请人提供）：明尼苏达核磁共振中心是上中西部核磁共振研究的领先网站。该中心的使命是通过核磁共振研究促进结构生物学的研究和教育。明尼苏达大学的核磁共振研究涵盖了广泛的生物医学研究，包括癌症，糖尿病，艾滋病毒，埃博拉病毒感染，肌肉收缩，以及心脏，炎症和神经退行性疾病。MNMR中心代表了来自校园周围的200多名用户以及美国各地的外部用户的主要资源。与MNMR中心相关的研究人员得到了42项NIH赠款的支持。自成立以来，每年发表约50篇论文。除了高场光谱仪外，MNMR中心还配备了两台瓦里安INOVA 600 MHz光谱仪和20年前的控制台。这些光谱仪以前代表了我们工厂中许多研究人员的主力;然而，这些过时的控制台和探针严重阻碍了新型NMR方法（用于溶液和固态NMR）的开发，NMR方法在突破性问题中的应用，以及研究生和博士后学生对这些机器的培训。安捷伦（前身为瓦里安）从NMR市场的退出使得为这些光谱仪寻找零件和支持变得几乎不可能。因此，我们建议用最先进的Bruker BioSpin Avance III HD控制台替换两台光谱仪中一台的当前控制台。选择布鲁克公司是基于电子器件的性能、从溶液到固态NMR模式转换的灵活性以及与当前Oxford 600 MHz磁体的兼容性。因此，新的购买不仅有利于该中心的现有用户，而且还将在高场NMR光谱仪上开辟大量的NMR时间，使MNMR中心能够为参与生物医学研究的内部和外部研究人员提供更广泛的网络服务。

 DESCRIPTION (provided by applicant): The Minnesota NMR Center is a leading site for NMR research in the Upper Midwest. The mission of the Center is to promote both research and education in structural biology by NMR research. NMR research at the University of Minnesota covers a broad range of biomedical research including cancer, diabetes, HIV, Ebola virus infections, muscle contractility, as well as heart, inflammatory, and neurodegenerative diseases. The MNMR Center represents the main resource for more than 200 users from around campus, as well as external users across the United States. Researchers associated with the MNMR Center are supported by 42 NIH grants. Since its inception, there have been approximately 50 papers published each year. In addition to high-field spectrometers, the MNMR Center is equipped with two Varian INOVA 600 MHz spectrometers with 20-year-old consoles. These spectrometers have previously represented the workhorses for many researchers in our facility; however, the development of the novel NMR methodologies (for both solution and solid-state NMR), the application of NMR methods to groundbreaking problems, as well as graduate and postdoctoral students' training on these machines are severely hampered by these obsolete consoles and probes. The withdrawal of Agilent (formerly Varian) from the NMR market made finding parts and support for these spectrometers almost impossible. Therefore, we propose to replace the current console for one of the two spectrometers with a state-of-the-art Bruker BioSpin Avance III HD console. The choice of Bruker is based both on performance of the electronics, flexibility in swapping from solution to solid-state NMR mode, as well as the compatibility of the current Oxford 600 MHz magnet. Therefore, the new purchase will not only benefit the current users of the Center, but will also open up a substantial amount of NMR time on the high-field NMR spectrometers, allowing the MNMR Center to serve an even more extensive network of internal and external investigators involved in biomedical research.