Multiscale Biophotonics: A Platform for Interdisciplinary Biomedical Research Training and Career Development

项目摘要 该IPERT计划的总体目标和具体目标是（1）为学员做好准备， 成功的多学科生物光子学事业和支持生物医学劳动力的发展。这将 通过以下方式实现：（2）提高我们的学员在多尺度方面的技术和操作熟练程度 生物光子学通过建模，计算，实验和基于问题的学习的整合， (3)为学员提供持续的专业发展辅导。这将是完成 通过在多尺度生物光子学领域建立基础技术和操作技能， 12-为期一天的现场短期课程在加州大学欧文分校。这个为期12天的短期课程利用了一个 集成模块化设计和基于证据的学习，包括（a）讲座，（B）技术 示范，（c）实验室结合动手数据采集与计算分析，使用我们的 定制虚拟组织模拟器（VTS）软件平台，（d）团队科学培训，（e）指导性顶点 （f）关于使用跨学科教学方法的客座讲座; 用生物光子学方法解决生物医学问题，（g）关于学术和工业 职业道路，以及（h）图尔斯学术和工业设施。学员技能的进一步应用和发展 发展将通过一个指导的顶点问题为基础的学习项目来完成， 短期课程结束后一年。与短期课程和为期一年的PBL项目平行， 我们将提供技术和专业指导。我们的技术指导旨在支持 生物光子学、仪器和测量设计、技术开发以及建模， 计算和使用开源计算生物光子学工具。我们的专业指导 该计划旨在帮助学员确定适当的短期和长期职业目标，并发展 战略来实现它们。该课程是专为跨学科小组的研究生，后， 博士研究员，以及科学家和工程师。我们提出了一个积极的外展计划， 传统上在STEM中代表性不足的学员以及来自地理区域的学员的参与 历史上获得NIH支持水平较低的地区。我们的目标是每个培训最多20人 年 总之，我们的计划为学员提供了技术基础和指导支持， 并应用多尺度生物光子学的综合技术能力来解决生物医学挑战。作为 在生物医学领域，需要将建模、计算和实验等专业知识进行整合， 研究和技术开发，拟议的计划推进NIGMS的计划目标， 培养具有与NIGMS部门最相关的专业知识的多样化生物医学研究队伍， 生物物理学、生物医学技术和计算生物科学。

PROJECT SUMMARY The overarching objectives and specific aims of this IPERT program are to (1) prepare trainees for successful multi-disciplinary Biophotonics careers and support biomedical workforce development. This will be achieved by (2) advancing the technical and operational proficiency of our trainees in Multiscale Biophotonics through an integration of modeling, computation, experiment, and problem-based learning, and (3) providing our trainees with sustained mentorship for professional development. This will be accomplished by establishing foundational technical and operational skills in the area of Multiscale Biophotonics during a 12-day onsite short course at the University of California, Irvine. This 12-day short course utilizes an integrated modular design and evidence based learning consisting of (a) lectures, (b) technology demonstrations, (c) laboratories combining hands-on data acquisition with computational analysis using our custom Virtual Tissue Simulator (VTS) software platform, (d) Team Science training, (e) mentored capstone problem-based learning (PBL) proposal development, (f) guest lectures on the use of an interdisciplinary Biophotonics approach to address biomedical problems, (g) panel discussions on academic and industrial career paths, and (h) tours of academic and industrial facilities. Further application and growth in trainee skill development will be accomplished by a mentored capstone problem-based learning project to be pursued for one year following the short course completion. In parallel with the short course and year-long PBL project, we will offer both technical and professional mentorship. Our technical mentorship aims to support Biophotonics, instrument and measurement design, technology development, as well as modeling, computation and usage of open-source Computational Biophotonics Tools. Our professional mentorship program aims to aid trainees in identifying appropriate short- and long-term professional goals and develop strategies to attain them. The course has been designed for interdisciplinary group of graduate student, post- doctoral researcher, and faculty scientists and engineers. We propose an aggressive outreach plan to support the participation of trainees who are traditionally underrepresented within STEM as well as from geographic regions that have historically received low levels of NIH support. We aim to train up to 20 individuals each year. In summary, our program provides a technical foundation and mentoring support for trainees to advance and apply an integrated technical proficiency in Multiscale Biophotonics to solve biomedical challenges. As the integration of expertise spanning modeling, computation and experiment are in demand in biomedical research and technology development, the proposed program advances NIGMS programmatic goals for training a diverse biomedical research workforce with expertise most relevant to the NIGMS Division of Biophysics, Biomedical Technology, and Computational Biosciences.