ECOG-ACRIN NCORP Research Base

描述(由申请人提供)：ECOG-ACRIN(E-A)代表着ECOG和ACRIN的合并，形成了一个合作小组，专注于改变实践的临床和转化性研究，从预防和早期发现到晚期疾病的管理及其影响。NCORP Research Base应用程序代表着一个雄心勃勃的计划，它延续了E-A在癌症预防和早期检测方面以社区为基础、高影响力的研究遗产，并将以患者为中心的结果嵌入治疗试验，并扩展了我们传统的研究基础活动，将重点扩大到研究差异、被诊断为癌症的老年人和年轻人的独特需求，以及癌症护理提供研究。特别强调早期发现和早期疾病治疗之间的关系，以努力减少过度治疗的发病率。还有一个重点是研究驱动症状和毒性的生物学，特别关注心脏毒性和紫杉烷相关的神经病变。与社区肿瘤学项目的关键合作将确保在患者接受护理的社区获得E-A NCORP试验。E-A利用NCI资助的现有资源以及由约10000名医生、科学家、护士、研究助理(RAS)、统计学家、生物医学信息技术专家和患者权益倡导者组成的网络，作为NCORP社区的一员，准备做出重大贡献。

DESCRIPTION (provided by applicant): ECOG-ACRIN (E-A) represents the merger of ECOG and ACRIN to form a cooperative group focused on practice-changing clinical and translational research across the cancer care continuum from prevention and early detection, through the management of advanced disease and its impact. This NCORP Research Base application represents an ambitious program that continues the E-A legacy of community based, high impact research in cancer prevention and early detection, and in embedding patient-centered outcomes into therapeutic trials, and extends our traditional research base activities to include an expanded emphasis on studying disparities, the unique needs of older and younger adults diagnosed with cancer, and cancer care delivery research. There is particular emphasis on the relationship between early detection and therapy of early disease in an effort to reduce morbidity of overtreatment. There is also an emphasis on studying the biology that drives symptoms and toxicity with a particular focus on cardiotoxicity and taxane related neuropathy. Key collaborations with community-based oncology programs will ensure access to E-A NCORP trials in communities where patients receive their care. Leveraging existing NCI-funded resources as well as a network of >10000 physicians, scientists, nurses, research associates (RAs), statisticians, biomedical information technologists, and patient advocates across approximately 600 institutions and organizations, E-A is poised to make significant contributions as a member of the NCORP community.