IMPROVED ANALYTIC MODELS FOR ANALYSIS OF DCE-MRI DATA SETS

用于 DCE-MRI 数据集分析的改进分析模型

• 批准号: 7723815
• 负责人: MITCHELL D. SCHNALL
• 金额: $ 1.09万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723815
• 关键词: American College of Radiology Imaging Network; Brain Neoplasms; Colorectal Cancer; Computer Retrieval of Information on Scientific Projects Database; Data Set; Diagnostic Neoplasm Staging; End Point; Evaluation; Funding; Grant; Image; Institution; Kinetics; Magnetic Resonance Imaging; Modeling; Perfusion; Protocols documentation; Renal Cell Carcinoma; Research; Research Personnel; Resources; Source; Spectrum Analysis; Tumor stage; United States National Institutes of Health; bevacizumab; image reconstruction; improved; response; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Analytic models for image reconstruction and analysis of DCE-MRI data sets in order to define kinetic parameters of tumor vascularity. These efforts will be applied toward central ACRIN DCE-MRI core lab analyses of several active imaging protocols which use DCE-MRI as an imaging endpoint. These include ACRIN-6676 (DCE-MRI for evaluation of renal cell carcinoma response to doublet targeted therapies), ACRIN 6677 (Brain tumor staging with perfusion MRI and spectroscopy), and ACRIN PA-4002 (DCE-MRI for evaluating early response of colorectal cancer to treatment with Bevacizumab).

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 用于图像重建和DCE-MRI数据集分析的分析模型， 肿瘤血管分布的动力学参数。 这些努力将应用于中央ACRIN DCE-MRI核心实验室分析了几种使用DCE-MRI作为 成像终点。 这些包括ACRIN-6676（用于评价肾细胞癌的DCE-MRI 双重靶向治疗的反应），ACRIN 6677（脑肿瘤分期与灌注MRI 和光谱学）和ACRIN PA-4002（DCE-MRI用于评估结直肠癌的早期反应 用贝伐单抗治疗癌症）。