2015 Apoptotic Cell Recognition & Clearance Gordon Research Conference & Gordon Research Seminar

 描述（由申请人提供）：细胞凋亡是有核细胞生理性死亡的主要机制，在后生动物生物体的整个生命过程中持续存在。细胞凋亡的数量（在人类中，每天约有1011个细胞死亡）需要一个有效的尸体识别和清除系统。事实上，凋亡细胞的快速清除是一个关键的稳态过程，代表了生理细胞死亡程序的最后一步。凋亡细胞的清除发生在没有炎症的情况下;事实上，凋亡细胞是有效的免疫抑制。凋亡细胞清除过程的失败与慢性炎症和系统性红斑狼疮、类风湿性关节炎和包括动脉粥样硬化在内的其他病理特征性自身免疫有关。虽然许多分子细节仍有待阐明，但近年来凋亡细胞识别和清除过程的大致轮廓已成为焦点。此外，很明显，这些机制在广泛的不同生理和病理过程中发挥着深远的作用，从神经网络的形成到微生物的发病机制。检查这些不同的设置都扩大了我们的赞赏的意义，凋亡过程，并提供了独特的见解，增强分子表征和促进治疗干预的发展。2015年凋亡细胞识别和清除戈登研究会议将探讨整个进化过程中凋亡细胞识别和清除机制的分子细节，包括凋亡免疫调节。有关凋亡细胞清除机制的致病性颠覆，神经元发育过程中的凋亡细胞清除和肺内稳态，凋亡识别和凝血之间的关系，以及对这些过程的衰老相关影响的问题也将是讨论的主要焦点。本次会议是唯一一次致力于综合探索这些主题的定期国际会议，将汇集不同的研究人员，他们具有不同基础和临床学科的专业知识， 这些领域的国际前沿，提出和讨论新的发现和重要问题。此外，这次会议将为更多的年轻科学家和研究生提供一个极好的机会，以海报形式展示他们的工作并参与讨论。部分海报主持人将被选中进行简短的演讲。随之而来的戈登研究研讨会将为学生和博士后研究员提供更多的机会，以网络，为GRC做准备，口头介绍他们的工作，并从同行那里获得经验和反馈。

 DESCRIPTION (provided by applicant): Apoptosis is the primary mechanism by which nucleated cells die physiologically and is ongoing throughout life in metazoan organisms. The magnitude of apoptosis (in humans, about 1011 cells die apoptotically each day) demands an efficient system for corpse recognition and clearance. Indeed, the rapid clearance of apoptotic cells is a critical homeostatic process, representing a final step of the physiological cell death program. The clearance of apoptotic cells occurs in the absence of inflammation; indeed, apoptotic cells are potently immunosuppressive. The failure of the process of apoptotic cell clearance has been linked to chronic inflammation and autoimmunity characteristic of systemic lupus erythematosus, rheumatoid arthritis, and other pathologies including atherosclerosis. While many molecular details remain to be elucidated, the broad outlines of the process of apoptotic cell recognition and clearance have come into focus over recent years. Further, it is apparent that these mechanisms play profound roles in a broad range of distinct physiological and pathological processes, ranging from the shaping neurological networks to microbial pathogenesis. The examination these disparate settings both enlarges our appreciation of the significance of the apoptotic processes and provides unique insights that enhance molecular characterizations and foster the development of therapeutic interventions. The 2015 Apoptotic Cell Recognition and Clearance Gordon Research Conference will explore molecular details of apoptotic cell recognition and clearance mechanisms throughout evolution, including apoptotic immune regulation. Issues pertaining to the pathogenic subversion of mechanisms of apoptotic cell clearance, apoptotic cell clearance during neuronal development and in lung homeostasis, the relationship between apoptotic recognition and coagulation, and aging-associated effects on these processes also will be major foci of discussion. This conference, which is the only regular international meeting dedicated to the integrated exploration of these topics, will bring together diverse group of investigators, with expertise in varied basic and clinical disciplines, who are at the forefront of these fields internationally, to present and discuss new findings and important issues. Moreover, this meeting will provide an outstanding opportunity for more junior scientists and graduate students to present their work in poster format and participate in discussions. Some poster presenters will be selected to give short talks. The accompanying Gordon Research Seminar will provide additional opportunities for students and post-doctoral fellows to network, prepare for the GRC, present their work orally, and gain experience and feedback from their peers.