The Milwaukee Clinical Site Hub

描述(由申请人提供)：弗罗伊德特医院急诊医学部与威斯康星医学院神经科和神经外科以及威斯康星州儿童医院合作提交了这份申请，以考虑继续作为NINDS紧急情况治疗试验网络(NETT)的临床站点中心，称为密尔沃基临床站点中心(MCCH)。MCSH将由首席研究员Tom P.Aufderheide医学博士、急诊医学教授兼副研究员John R.Lynch医学博士、神经病学重症监护计划和神经重症监护病房主任以及Dennis J.Maiman医学博士、神经外科教授兼主任负责协调。我们的蓝图利用了MCW作为JCAHO认证的主要区域卒中中心的巨大基础设施，并部署了一批协作中心和威斯康星州东南部的MCW临床和翻译科学研究所(CTSI)。密尔沃基县紧急医疗服务系统实施选定的NETT协议，是医院外知情同意临床研究例外情况的全国领先者，由MCCH指导。MCSH显著扩大了其足迹，包括三个新的密尔沃基社区Spoke(圣卢克医疗中心，哥伦比亚-圣卢克)。玛丽医院和哥伦比亚-圣彼得堡。玛丽医院Ozaukee)，所有JCAHO认证的中风中心，以及三个新的地区SPOKE：1)威斯康星大学医院，麦迪逊，WL，2)拉什大学医学中心，伊利诺伊州芝加哥，和3)仁慈医院，圣路易斯，密苏里州。MCSH的目标是：1)扩大我们的中心和分支机构的足迹，以覆盖大量患有神经急症的不同种族的患者；2)利用我们以前成功的NETT经验提供领导和研究支持，以最大限度地提高中心的成功研究实施；3)利用扩展的研究基础设施，最大限度地提高研究实施和患者捕获的效率，以及4)协调这一协作网络，以实现或超过NETT研究和患者在未来五年的应计目标。

DESCRIPTION (provided by applicant): The Department of Emergency Medicine of Froedtert Hospital in collaboration with the Departments of Neurology and Neurosurgery at the Medical College of Wisconsin (MCW), and Children's Hospital of Wisconsin are submitting this application for consideration to continue as a Clinical Site Hub of the NINDS Emergencies Treatment Trials Network (NETT) to be known as the Milwaukee Clinical Site Hub (MCSH). The MCSH will be coordinated by Principal Investigator, Tom P. Aufderheide, MD, Professor of Emergency Medicine, Co-lnvestigator, John R. Lynch, MD, Director of the Neurology Critical Care Program and Neurointensive Care Unit, and Dennis J. Maiman, MD, PhD, Professor and Chair of the Department of Neurosurgery. Our blueprint capitalizes on MCW's enormous infrastructure as a major JCAHO-certified Regional Stroke Center and deploys a cadre of collaborative Centers and the MCW Clinical and Translational Science Institute of Southeast Wisconsin (CTSI). The Milwaukee County Emergency Medical Services System, implementing selected NETT protocols, is a national leader in out-of-hospital exception from informed consent clinical research and is directed from the MCSH. MCSH has significantly expanded its footprint to include three new Milwaukee Community Spokes (St. Luke's Medical Center, Columbia-St. Mary's Hospital, and Columbia-St. Mary's Hospital Ozaukee), all JCAHO-certified Stroke Centers, as well as three new Regional Spokes: 1) The University of Wisconsin Hospital, Madison, Wl, 2) Rush University Medical Center, Chicago, IL, and 3) Mercy Hospital, St. Louis, MO. The MCSH aims to: 1) Expand our Hub and Spoke footprint to capture a sizable population of ethnically diverse patients with neurological emergencies; 2) Utilize our previous successful NETT experience to provide leadership and research support to maximize the Hub's successful study implementation; 3) Capitalize on expanded research infrastructure to maximize efficiency of study implementation and patient capture, and 4) Orchestrate this collaborative network to meet or exceed NETT research and patient accrual goals during the next five years.