Physical Activity, Energy Balance, and Cancer

这些目标将通过以下方式实现：a)评估肥胖、能量平衡和体力活动与癌症发病率和存活率的关系；b)改进能量摄入、输出和身体表型的评估；c)评估生物标记物，以确定包括炎症细胞因子(CRP、IL-6、TNF-α)、生长因子及其主要结合蛋白(IGF-1和IGFBP-3)、类固醇激素(睾酮、雌激素、SHBG)与癌症和中间产物(如体重减轻和体重增加)有关的机制，例如代谢组学在评估肥胖、能量平衡、体力活动和身体表型以及与癌症风险之间的关系。虽然这个项目适用于所有癌症，但其特定的癌症包括乳腺癌、结直肠癌和胰腺癌。

The goals will be achieved by a) evaluating obesity, energy balance, and physcial activity in relation to cancer incidence and survival; b) Improving assessment of energy intake, output, and body phenotype; c) Evaluating biomarkers to determine mechanisms including inflammatory cytokines (CRP, IL-6, TNF-alpha), growth factors and their major binding proteins (IGF-1 and IGFBP-3), steroid hormones (testosterone, estrogen, SHBG) in relation to cancer and intermediate outs comes such as weight loss and weight gain d) evaluate novel such as metabolomics in assessing obesity, energy balance, and physical activity and body phenotype and in relation to cancer risk. Although this project is for all cancer, its particular cancer includes breast, colorectal, and pancreatic cancer.