Physiology of Inflammatory Arthritis in High Resolution

标题：高分辨率炎性关节炎的生理学 摘要 开发新的成像技术来识别和验证炎症性关节炎的生物标记物 引起广泛关注，并与医生、医学研究人员和科学实体的共同目标保持一致。 在地下组织中呈现高度敏感的光学信息，其空间分辨率可与 超声(US)成像，新兴的光声(PA)成像为早期 诊断和预后，以及评估关节炎的治疗，通过提供额外的新功能 关于疾病活动的信息可以有效地与更广泛和更成熟的信息相结合 接受了肌肉骨骼超声成像。我们目前对关节炎患者的研究成功地证明了 US-PA联合系统能够识别和表征人类外周的炎症 关节，基于血液动力学和代谢变化的检测，包括充血和缺氧。 这些是反映代谢需求增加的滑膜炎的重要和早期的生理生物标志物。 炎性滑膜组织供氧相对不足。 我们对关节炎患者的研究取得了初步成功，受到鼓舞，我们建议进一步推进 US-PA双重成像技术在炎性关节炎临床治疗中的应用我们的终极目标 是开发一种具有成本效益和护理点的关节成像设备，能够进行早期治疗修改 和个性化医疗，改变了风湿病临床目前的程序。在这项研究中， 了解了所提出的成像技术的临床价值，我们将确定一组稳健、可靠的 可重复、精确的生物标志物，可反映炎性关节炎的早期病理变化 以及它对治疗的反应。中心假设是一组3D US和PA生物标记物可以 通过建议的成像技术进行评估，可以更好地评估关节炎疾病状态和 治疗效果优于常规二维超声成像。为了检验这一假设， 实现以下具体目标： 目的1：建立一种通过定量3D US和PA来评估炎症性关节炎疾病活动性的方法 反映特定关节潜在病理状态的生物标记物 目的2：评价这些生物标志物在评价局部关节病理状态中的作用 通过对一种成熟的动物模型的研究来影响关节炎 目的3.评估US-PA可评估的已识别的影像生物标记物的临床价值 双模式技术在炎症性关节炎患者中的初步研究

Title: Physiology of Inflammatory Arthritis in High Resolution Abstract Development of new imaging technologies to identify and validate biomarkers of inflammatory arthritic disease is of broad interest and aligned with common goals of physicians, medical researchers, and scientific entities. Presenting highly sensitive optical information in subsurface tissue with spatial resolution comparable to ultrasound (US) imaging, the emerging photoacoustic (PA) imaging offers significant advantages to early diagnosis and prognosis, as well as assessing the treatment of arthritis, by providing additional new functional information about the disease activity that can be effectively combined with more established and widely accepted musculoskeletal US imaging. Our current research on arthritis patients has successfully demonstrated that a combined US-PA system is capable of identifying and characterizing inflammation in human peripheral joints, based on the detection of hemodynamic and metabolic changes, including both hyperemia and hypoxia. These are important and early physiological biomarkers of synovitis reflecting the increased metabolic demand and the relatively inadequate oxygen delivery of the inflammatory synovial tissue. Encouraged by the initial success of our study on arthritis patients, we propose to further advance the translation of US-PA dual imaging technology to clinical management of inflammatory arthritis. Our ultimate goal is to develop a cost-efficient and point-of-care joint imaging device that can enable early treatment modification and personalized medicine, changing the current procedures in rheumatology clinic. In this research, to understand the clinical value of the proposed imaging technology, we will identify a group of robust, reliably reproducible, and precise biomarkers that can reflect the early pathological changes of inflammatory arthritis and its response to treatment. The central hypothesis is that a group of 3D US and PA biomarkers that can be evaluated by the proposed imaging technology can lead to better assessment of arthritis disease state and treatment response than those evaluated by conventional 2D US imaging. To examine this hypothesis, following specific aims will be accomplished: Aim 1: Develop a method to assess inflammatory arthritis disease activity by quantifying 3D US and PA biomarkers that reflect the underlying pathological condition of specific joints Aim 2: Evaluate the performance of these biomarkers in assessing the pathological condition in local joints affected by arthritis through the study on a well-developed animal model Aim 3. Evaluate the clinical value of the identified imaging biomarkers that can be assessed by the US-PA dual-modality technology via a pilot study on patients affected by inflammatory arthritis