Physiology of Inflammatory Arthritis in High Resolution

高分辨率炎症性关节炎的生理学

• 批准号: 10205976
• 负责人: XUEDING WANG
• 金额: $ 62.41万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-06 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10205976
• 关键词: 3-Dimensional; 3D ultrasound; Adjuvant Arthritis; Affect; Algorithmic Analysis; Animal Model; Arthritis; Biological Markers; Clinic; Clinical; Clinical Management; Clinical Research; Detection; Development; Devices; Disease; Early Diagnosis; Early treatment; Ensure; Feasibility Studies; Frequencies; Goals; Grant; Hand; Hemoglobin; Human; Hyperemia; Hypoxia; Image; Imaging Device; Imaging technology; Inflammation; Inflammatory; Inflammatory Arthritis; Joints; Lasers; Lead; Measures; Medical; Metabolic; Methods; Michigan; Modality; Modeling; Modification; Optics; Outcomes Research; Oxygen; Parents; Pathologic; Patients; Performance; Peripheral; Pharmacological Treatment; Phase; Physicians; Physiological; Physiology; Pilot Projects; Point-of-Care Systems; Procedures; Process; Prognosis; Prospective Studies; Radiology Specialty; Rattus; Reproducibility; Research; Research Personnel; Resolution; Rheumatology; Robotics; Scanning; Swelling; Synovitis; System; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Translating; Translations; Treatment outcome; Ultrasonography; Universities; base; biomarker performance; clinical application; cost efficient; experience; experimental study; hemodynamics; human imaging; human subject; image processing; imaging biomarker; imaging modality; imaging system; interest; joint inflammation; musculoskeletal ultrasound; novel imaging technology; personalized medicine; photoacoustic imaging; point of care; prototype; response; soft tissue; success; tissue biomarkers; treatment response; volunteer

Title: Physiology of Inflammatory Arthritis in High Resolution Abstract Development of new imaging technologies to identify and validate biomarkers of inflammatory arthritic disease is of broad interest and aligned with common goals of physicians, medical researchers, and scientific entities. Presenting highly sensitive optical information in subsurface tissue with spatial resolution comparable to ultrasound (US) imaging, the emerging photoacoustic (PA) imaging offers significant advantages to early diagnosis and prognosis, as well as assessing the treatment of arthritis, by providing additional new functional information about the disease activity that can be effectively combined with more established and widely accepted musculoskeletal US imaging. Our current research on arthritis patients has successfully demonstrated that a combined US-PA system is capable of identifying and characterizing inflammation in human peripheral joints, based on the detection of hemodynamic and metabolic changes, including both hyperemia and hypoxia. These are important and early physiological biomarkers of synovitis reflecting the increased metabolic demand and the relatively inadequate oxygen delivery of the inflammatory synovial tissue. Encouraged by the initial success of our study on arthritis patients, we propose to further advance the translation of US-PA dual imaging technology to clinical management of inflammatory arthritis. Our ultimate goal is to develop a cost-efficient and point-of-care joint imaging device that can enable early treatment modification and personalized medicine, changing the current procedures in rheumatology clinic. In this research, to understand the clinical value of the proposed imaging technology, we will identify a group of robust, reliably reproducible, and precise biomarkers that can reflect the early pathological changes of inflammatory arthritis and its response to treatment. The central hypothesis is that a group of 3D US and PA biomarkers that can be evaluated by the proposed imaging technology can lead to better assessment of arthritis disease state and treatment response than those evaluated by conventional 2D US imaging. To examine this hypothesis, following specific aims will be accomplished: Aim 1: Develop a method to assess inflammatory arthritis disease activity by quantifying 3D US and PA biomarkers that reflect the underlying pathological condition of specific joints Aim 2: Evaluate the performance of these biomarkers in assessing the pathological condition in local joints affected by arthritis through the study on a well-developed animal model Aim 3. Evaluate the clinical value of the identified imaging biomarkers that can be assessed by the US-PA dual-modality technology via a pilot study on patients affected by inflammatory arthritis

标题：炎症性关节炎的高分辨率生理学 摘要 开发新的成像技术以识别和验证炎性关节炎疾病的生物标志物 具有广泛的兴趣，并与医生、医学研究人员和科学实体的共同目标相一致。 在亚表面组织中呈现高度敏感的光学信息，其空间分辨率可与 超声（US）成像，新兴的光声（PA）成像提供了显着的优势，早期 诊断和预后，以及评估关节炎的治疗，通过提供额外的新功能， 关于疾病活动的信息，可以有效地结合更广泛的 接受肌肉骨骼超声成像。我们目前对关节炎患者的研究已经成功地证明了 联合的US-PA系统能够识别和表征人类外周血中的炎症， 关节，基于血液动力学和代谢变化的检测，包括充血和缺氧。 这些是反映代谢需求增加的滑膜炎的重要和早期生理生物标志物 以及炎症性滑膜组织的氧气输送相对不足。 在我们对关节炎患者的研究取得初步成功的鼓舞下，我们建议进一步推进 将US-PA双重成像技术转化为炎症性关节炎的临床治疗。我们的最终目标 是开发一种具有成本效益的即时关节成像设备， 和个性化医疗，改变目前的程序在风湿病诊所。在这项研究中， 了解所提出的成像技术的临床价值，我们将确定一组强大的，可靠的 可重复、精确的生物标志物，可反映炎性关节炎的早期病理变化 以及对治疗的反应中心假设是，一组3D US和PA生物标志物，可以 通过所提出的成像技术进行评估可以更好地评估关节炎疾病状态， 治疗反应比传统的2D US成像评价。为了验证这个假设， 将实现以下具体目标： 目的1：开发一种通过量化3D US和PA评估炎性关节炎疾病活动的方法 反映特定关节的潜在病理状况的生物标志物 目的2：评价这些生物标志物在评估局部关节病理状况中的性能 受关节炎的影响，通过对一个成熟的动物模型的研究， 目标3。评价可由US-PA评估的已识别成像生物标志物的临床价值 通过对受炎性关节炎影响的患者进行试点研究的双模态技术

项目成果

Photoacoustic microscopy: a potential new tool for evaluation of angiogenesis inhibitor.

• DOI: 10.1364/boe.4.002657
• 发表时间: 2013-11
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Sung-Liang Chen;Joseph P. Burnett;Duxin Sun;Xunbin Wei;Zhixing Xie;Xueding Wang

Photoacoustic spectrum analysis for microstructure characterization in biological tissue: analytical model.

• DOI: 10.1016/j.ultrasmedbio.2015.01.010
• 发表时间: 2015-05
• 期刊: ULTRASOUND IN MEDICINE AND BIOLOGY
• 影响因子: 2.9
• 作者: Xu, Guan;Fowlkes, J. Brian;Tao, Chao;Liu, Xiaojun;Wang, Xueding
• 通讯作者: Wang, Xueding

Photoacoustic Imaging of COVID-19 Vaccine Site Inflammation of Autoimmune Disease Patients.

• DOI: 10.3390/s23052789
• 发表时间: 2023-03-03
• 期刊: Sensors (Basel, Switzerland)
• 作者: Jo J;Mills D;Dentinger A;Chamberland D;Abdulaziz NM;Wang X;Schiopu E;Gandikota G
• 通讯作者: Gandikota G

Air-coupled ultrasound detection using capillary-based optical ring resonators.

• DOI: 10.1038/s41598-017-00134-7
• 发表时间: 2017-03-01
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Kim KH;Luo W;Zhang C;Tian C;Guo LJ;Wang X;Fan X
• 通讯作者: Fan X

Interstitial assessment of aggressive prostate cancer by physio-chemical photoacoustics: An ex vivo study with intact human prostates.

通过物理化学光声学对侵袭性前列腺癌进行间质评估：对完整人类前列腺的离体研究。

• DOI: 10.1002/mp.13061
• 发表时间: 2018-06-23
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Huang S;Qin Y;Chen Y;Pan J;Xu C;Wu D;Chao WY;Wei JT;Tomlins SA;Wang X;Fowlkes JB;Carson PL;Cheng Q;Xu G
• 通讯作者: Xu G