Improving Diagnostic and Management Tools for Neurocysticercosis (Peru-JHU TMRC Program)

改进人类囊虫病的诊断和管理工具/秘鲁-JHU TMRC概述 主要研究者/项目负责人（最后一名、中间一名、第一名）：GARCIA，Héctor H. 改进脑囊虫病的诊断和管理工具 (Perú-JHU TMRC计划） 项目摘要 猪带绦虫脑囊虫病仍然是大多数国家癫痫发作和癫痫的主要原因。 世界我们的团队在过去的25年里一直在NCC工作，并提供了具有里程碑意义的 有助于其研究，诊断和治疗。此TMRC应用程序基于最近的ICIDR 应用和使用在此期间开发和获得的资源，包括体外样品库， 和动物模型（包括最近在我们的环境中开发的三种新模型）以及最近可用的 纳米粒子诊断和基因组数据。我们的目标是提供更好的诊断和监测 以及更有效的抗寄生虫和寄生虫疗法，以尽量减少脑损伤 寄生虫死亡之后早期诊断和改善治疗应导致减少的频率 继发于NCC的癫痫。 秘鲁-JHU TMRC应用程序框架三个组成部分的研究项目和三个核心， 提供一个功能齐全的研究网络，并利用疾病的地方性和我们的 秘鲁现有的非常成功的研究网络。科学核心将作为基础， 这两个研究项目所使用的，并将包括在体外和动物模型，分子 生物技术和分析过程，并将得到数据管理和 生物统计学核心。包括伦理和动物护理部门在内的管理核心将确保完全合规 与当地和国际研究规范和法规。该方案包括三个项目： 这三个研究项目是组件1 -改进的诊断分析， 退化性脑囊虫病;组分2 -用于监测人类治疗效果的生物标志物 脑囊虫病和组件3 -提高对脑炎症的认识和治疗 脑囊虫病该计划将利用这些研究项目的具体目标 提供一套统一的有前途的工具，准备在临床试验中进行测试，并转化为人类使用。

Improving Diagnostic and Management Tools for Human Cysticercosis / Perú-JHU TMRC PROGRAM OVERVIEW Principal Investigator / Program Director (last, middle, first): GARCIA, Héctor H. Improving Diagnostic and Management Tools for Neurocysticercosis (Perú-JHU TMRC Program) PROJECT SUMMARY Taenia solium neurocysticercosis continues to be a major cause of seizures and epilepsy in most of the world. Our group has continuously worked in NCC for the last 25 years and has provided landmark contributions to its study, diagnosis, and treatment. This TMRC application builds on a recent ICIDR application and uses resources developed and acquired over this period including sample libraries, in vitro and animal models (including three new models recently developed in our settings) and recently available nanoparticle diagnostics and genomic data. Our objective is to provide improved diagnostics and monitoring as well as more efficient antiparasitic and antiinflammatory therapies in order to minimize brain damage which follows parasite death. Early diagnosis and improved treatment should result in reduced frequency of epilepsy secondary to NCC. The Perú-JHU TMRC application frames three component Research Projects and three Cores to provide a fully functional research network and take advantage of the endemicity of the disease and our existing, highly successful research network in Perú. The scientific core will serve as the foundation to be used by the two research projects, and will include capacities for in vitro and animal models, molecular biology techniques, and analytic processes, and will be supported by the Data Management and Biostatistics Core. An Administrative Core including Ethics and Animal Care units will ensure full compliance with local and international research codes and regulations. Three projects comprise the program: The three research projects are Component 1 - Improved Diagnostics Assays for Viable or Degenerating Neurocysticercosis; Component 2 - Biomarkers for Monitoring Treatment Efficacy in Human Neurocysticercosis, and Component 3 - Improving the Understanding and Treatment of Brain Inflammation in Neurocysticercosis. The Program will take advantage of the specific objectives of these research projects to provide a unified set of promising tools ready to be tested in clinical trials and translated to human use.