Training in the Science of Co-Occurring Disorders

描述（由申请人提供）：该提案将在跨学科研究，共同发生的物质使用和其他精神障碍（COD）的发展领域建立一个独特的培训计划。鉴于在成瘾性疾病患者中，COD更像是一种常态，而非例外，对这种科学关注的需求至关重要。这个项目的哲学主张，要有效地影响成瘾和精神疾病的问题，人们必须充分意识到它们的共存，病因，现象学和临床表现。此外，临床方法和服务于成瘾和精神疾病患者的医疗保健系统的知识对于告知实验室和临床研究中要提出的问题是必要的。将COD作为主要观点并不是一种被广泛接受的培训科学家的方法。在NIDA的大约60个T32项目中，没有一个包括合并症、双重诊断或其他关注COD的指标。建立优先考虑这一领域培训的项目，将有助于开发先进的方法，寻找创新的战略，为患有COD的人提供服务。我们建议利用达特茅斯独特的资源和机会来开发这样一个项目。六个相互联系的小组将在社会、行为和神经生物学机制、治疗发展（社会心理和药理学）、技术辅助治疗和传播以及卫生服务实践和实施方面提供研究机会。教师队伍包括COD研究领域的杰出领导者，具有培养科学家的悠久历史的医学博士和博士研究人员，以及致力于建立COD结构化培训计划的支持团队。研究团队包括神经科学家、行为健康技术专家、临床试验和应急管理专家、人类学家、统计学家、经济学家和家庭治疗师。目前，该学院拥有27个美国国立卫生研究院资助项目（NIDA [12], NIAAA [4], NIMH [8], NCI [2], NICHD[1]），以及多个基金会、教育部和VA支持的研究。在过去的10年里，在核心教师的指导下，博士生和博士后共同撰写了150多篇与他们的培训活动相关的出版物，其中约50%是第一作者。本项目在资助初期培养5-7名博士预科生和9-11名博士后。教职员工和参与研究项目的卓越声誉，加上严格的学员选择标准和吸引不同学员的坚定承诺，将确保科学家的发展，他们对科学必须解决的问题范围有更大的了解，以有效地影响成瘾和精神疾病。这批学生将更具备广泛的专业知识领域，并致力于用多学科方法解决他们感兴趣的问题。

DESCRIPTION (provided by applicant): This proposal will establish a unique training program in a developing area of transdisciplinary research, co-occurring substance use and other mental disorders (COD). The need for this scientific focus is vital given that COD is more the norm than the exception among those with addictive disorders. The philosophy of this program asserts that to effectively impact the problems of addiction and mental illness, one must be fully aware of their co-existence, etiologies, phenomenology, and clinical manifestations. Moreover, knowledge of clinical approaches and the healthcare systems that serve those with addiction and mental illness is necessary to inform the questions to be asked in laboratory and clinical research studies. Embracing COD as a primary perspective is not a widely accepted approach for the training of scientists. Of NIDA's approximate sixty T32 programs, none include the words co-morbidity, dual diagnosis, or other indicators of a focus on COD. Establishing programs that prioritize training in this area will lead to the development of advanced methods for finding innovative strategies for serving those with COD. We propose to develop such a program by utilizing the unique resources and opportunities available at Dartmouth. Six interconnected groups will provide research opportunities in social, behavioral, and neurobiological mechanisms, treatment development (psychosocial and pharmacological), technology-assisted treatment and dissemination, and health services practices and implementation. Faculty include preeminent leaders in COD research, MD and PhD investigators with strong histories of training scientists, and a team of support faculty committed to establishing a structured training program in COD. Research teams include neuroscientists, behavioral health technologists, clinical trials and contingency management experts, anthropologists, statisticians, economists, and family therapists. Currently the faculty has 27 NIH-funded projects (NIDA [12], NIAAA [4], NIMH [8], NCI [2]; NICHD [1]), and multiple foundation, Department of Education, and VA supported studies. Predoctoral and postdoctoral students mentored by core faculty in the past 10 years have co-authored over 150 publications related to their training activities and were first author on approximately 50% of those. This program will train 5-7 predoctoral and 9-11 postdoctoral students in the initial funding period. The stellar reputation of the faculty and participating research programs, in concert with rigorous criteria for trainee selection and a strong commitment to attracting diverse trainees, will ensure the development of scientists with greater knowledge about the scope of issues that science must address to effectively impact addiction and mental illness. This cohort will be more equipped with broad areas of expertise and a commitment to multidisciplinary approaches to their questions of interest.