Device for rapid extraction of rare pathogens from raw samples

第1个，共2个 导致败血症的医院获得性感染是致命的、昂贵的，而且越来越多。 很普通。病原菌的快速诊断、抗微生物治疗和鉴定 改善结果和降低成本的关键。诊断和菌株鉴定必须 提高。血液培养(BC)和分子诊断(MDX)新技术 从血液中提纯和浓缩病原体的技术前景看好，但更好的技术将是 对下一代诊断至关重要。我们将开发一种设备来净化和 直接从大容量(≥10毫升)全血中浓缩病原体。与现有的不同 技术，我们的技术将实现高绑定效率的过滤器与非 空流动单元的堵塞特性。

1 of 2 Hospital acquired infection that leads to sepsis is deadly, expensive, and increasingly common. Rapid diagnosis, anti-microbial treatment, and identification of the pathogen strain is key to improving outcomes and reducing costs. Diagnosis and strain identification must improve. Novel techniques for blood culture (BC) and molecular diagnostics (MDx) are promising, but better technology for pathogen purification and concentration from blood will be essential for the next generation of diagnostics. We will develop a device to purify and concentrate pathogens directly from a large volume (≥10 mL) of whole blood. Unlike existing techniques, our technology will achieve the high binding efficiency of a filter with the non- clogging properties of an empty flow cell.