Rapid point-of-care molecular test for HCV VL
HCV VL 快速护理点分子检测
基本信息
- 批准号:10330833
- 负责人:
- 金额:$ 28.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-01 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:5&apos Untranslated RegionsAffectAlgorithmsAntibodiesAntiviral AgentsBiological AssayBloodChemistryCirrhosisClinic VisitsCold ChainsComprehensive Health CareDetectionDevelopmentDevicesDiagnosisDiagnosticDiagnostic testsDiffusionDigit structureDiseaseElectricityEnvironmentExposure toFluorescenceFundingFutureGenotypeGoalsGoldHCV screeningHIVHIV-1Hepatitis B VirusHepatitis CHepatitis C AntibodiesHepatitis C PrevalenceHepatitis C TherapyHepatitis C virusHigh PrevalenceIndividualInfectionInflammatoryKineticsLaboratoriesLettersLiver FailureLiver diseasesMethodsMicrofluidic MicrochipsMicrofluidicsMolecularNucleic Acid Amplification TestsNucleic AcidsOrangesPatientsPerformancePhasePolymerasePopulationPopulations at RiskPreparationPrimary carcinoma of the liver cellsProductionQuantitative Reverse Transcriptase PCRReagentResourcesRestRoutine Diagnostic TestsRunningSamplingSensitivity and SpecificitySpecificitySpecimenSystemTechnologyTestingTubeViral Load resultViremiaVulnerable PopulationsWorkamplification detectionantibody testassay developmentbasecomorbiditycostdesigndetection limitdiagnostic assayfollow-upisothermal amplificationmagnetic beadsnucleic acid purificationphase 2 studypoint of careprogramsrecombinaserisk minimizationscale upsuccesstreatment strategy
项目摘要
ABSTRACT
Hepatitis C, the inflammatory liver disease caused by hepatitis C virus (HCV), claims approximately 400,000
lives each year from secondary hepatocellular carcinoma and cirrhosis-induced liver failure. Direct-acting
antiviral agents can cure > 95% of the estimated 71 million cases of hepatitis C found globally, yet because of
underdiagnosis, only 7% of patients are currently receiving treatment. The diagnostic testing algorithm for HCV
necessitates multiple clinic visits. Individuals in vulnerable populations often lack the means to meet this high
follow-up burden. Increasing the prevalence of HCV treatment to reflect the 95% cure rate requires simplification
of diagnostic testing. To this end we will develop a sample-to-answer HCV viral load (VL) test that meets or
exceeds the minimal acceptable criteria as defined by the hepatitis C global stakeholder consortium.
To achieve this goal, we will combine Redbud Labs’ expertise in microfluidics and systems with the diagnostic
assay development expertise of the Diagnostics Program at PATH (Seattle, WA). In Aim 1 Redbud Labs will
optimize each assay step to the microfluidic environment using Redbud technologies and commercially
available reagents. In Aim 2 PATH will design assay primers and probes. In Aim 3 Redbud Labs will validate
the assay by performing it end-to-end using a breadboard system. Redbud technologies are production-ready,
which will minimize the risk of degradation in assay performance as we move through cartridge integration in
future Phase II work.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jay Kenneth Fisher其他文献
Jay Kenneth Fisher的其他文献
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{{ truncateString('Jay Kenneth Fisher', 18)}}的其他基金
Improving extraction success of FFPE samples with automated and reliable microfluidic sample preparation
通过自动化、可靠的微流体样品制备提高 FFPE 样品的提取成功率
- 批准号:
10547272 - 财政年份:2022
- 资助金额:
$ 28.87万 - 项目类别:
System for unitary automation of library preparation
文库制备统一自动化系统
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10395282 - 财政年份:2022
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$ 28.87万 - 项目类别:
MEMS-enhanced solid-phase isothermal amplification for rapid, multiplexed molecular diagnostics
MEMS 增强固相等温放大,用于快速、多重分子诊断
- 批准号:
10484147 - 财政年份:2022
- 资助金额:
$ 28.87万 - 项目类别:
A modular platform for infectious disease surveillance at point-of-need.
用于按需监测传染病的模块化平台。
- 批准号:
10021318 - 财政年份:2020
- 资助金额:
$ 28.87万 - 项目类别:
A modular platform for infectious disease surveillance at point-of-need.
用于按需监测传染病的模块化平台。
- 批准号:
10633681 - 财政年份:2020
- 资助金额:
$ 28.87万 - 项目类别:
A modular platform for infectious disease surveillance at point-of-need.
用于按需监测传染病的模块化平台。
- 批准号:
10697143 - 财政年份:2020
- 资助金额:
$ 28.87万 - 项目类别:
Point-of-care HIV viral load system using RPA and MXR
使用 RPA 和 MXR 的护理点 HIV 病毒载量系统
- 批准号:
10484628 - 财政年份:2019
- 资助金额:
$ 28.87万 - 项目类别:
Point-of-care HIV viral load system using RPA and MXR
使用 RPA 和 MXR 的护理点 HIV 病毒载量系统
- 批准号:
10665089 - 财政年份:2019
- 资助金额:
$ 28.87万 - 项目类别:
Device for rapid extraction of rare pathogens from raw samples
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- 批准号:
9202652 - 财政年份:2016
- 资助金额:
$ 28.87万 - 项目类别:
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