IL-27 and Treg cells

描述（由申请人提供）：在美国，弓形虫是食源性死亡的第二大原因，超过6000万人持续感染该微生物，这种感染是许多原发性或获得性弓形虫病患者的担忧。 T细胞介导的免疫缺陷。由于T.弓形虫被分类为B类生物防御病原体。平衡保护性和病理性免疫发展的能力是决定这种感染结果的关键。 该提案研究了细胞因子IL-27在调节性T细胞的独特群体中的作用，以限制炎症，并且广泛适用于理解这种细胞因子如何可用作治疗。

DESCRIPTION (provided by applicant): In the US, Toxoplasma gondii is the second leading cause of food borne mortality and more than 60 million people are persistently infected with this organism and this infection is a concern in many patients with primary or acquired defects in T cell mediated immunity. Due to the ease of transmission and its ability to cause severe disease, T. gondii is classified as a Class B Biodefense pathogen. The ability to balance the development of protective and pathological immunity is key in determining the outcome of this infection. This proposal studies the role of the cytokine IL-27 in controllinga unique population of regulatory T cells to limit inflammation and is broadly applicable to understanding how this cytokine may be useful as a therapy.