Training in the Genetics and Genomics of Mental Disorders

 描述（由申请人提供）：本申请要求再支持五年的机构国家研究服务奖，以支持遗传流行病学，分子遗传学和神经生物学的多学科博士后培训。我们要求支持四个博士后（1医学博士。（3 PhD）研究员在遗传方法学，家庭流行病学和行为遗传学，基因图谱和生物信息学，分子遗传学和基因组学的培训。除了在一个主要领域的培训，研究员将被鼓励获得广泛的了解精神病遗传学的各种技能，以促进他们的合作（和领导）跨学科的研究团队。研究金通常为期三年，但对于具有相关经验的人来说，一年或两年就足够了。将招募具有各种背景的研究员，包括;心理学，精神病学，遗传学，统计学，数学，人类学，社会学，生物学和神经科学。培训方案采用学徒模式，将一名或多名经验丰富的导师指导下的研究与通过研讨会、教学课程和个人阅读进行的更正式的培训相结合。该计划的主要优势是：（i）一个大型多学科小组的参与资金充足的导师（n=23）与统计和计算遗传学，分子遗传学和神经科学的专业知识;（ii）数量和质量性状的研究，以及多变量表型分析方法的开发，以及（iii）主要流行病学和遗传数据集的可用性（表型和基因型）。研究员可以参与正在进行的精神分裂症，双相情感障碍，阿尔茨海默病，自闭症，ADH，CNS活动的电生理测量，人格特征和尼古丁依赖的全基因组关联研究（GWAS）。我们预计序列数据分析将成为未来的重点。该计划的指导者有许多联邦和非联邦资助的赠款，为精神病学遗传学的各个方面提供了许多培训机会。该计划位于全国领先的医学院之一，拥有丰富的基础和应用遗传研究和教育机会。因此，我们期待着来自不同知识背景的科学家和医学科学家的成功指导和研究培训的悠久传统继续下去。

 DESCRIPTION (provided by applicant): This application requests a further five years of support for an Institutional National Research Service Award to support multidisciplinary post-doctoral training in Genetic Epidemiology, Molecular Genetics and Neurobiology. We request support for four postdoctoral (1 M.D. and 3 Ph.D.) fellows for training in Genetic Methodology, Family Epidemiology and Behavior Genetics, Gene Mapping and Bioinformatics, Molecular Genetics, and Genomics. In addition to training in a primary area, fellows will be encouraged to obtain a broad understanding of the diverse skills in Psychiatric Genetics to facilitate their collaboration in (and leadership of) cross- disciplinary research teams. The fellowship will usually last three years, but one or two years may suffice for those with much pertinent experience. Fellows with a wide variety of backgrounds will be recruited including; Psychology, Psychiatry, Genetics, Statistics, Mathematics, Anthropology, Sociology, Biology, and Neuroscience. The training program uses an apprenticeship model, combining research under the mentorship of one or more experienced mentors with more formal training through seminars, didactic courses and individual reading. Major strengths of the program are; (i) the participation of a large multidisciplinary group of well-funded preceptors (n=23) with expertise in statistical and computational genetics, molecular genetics and neuroscience; (ii) the study of quantitative and qualitative traits and the development of methods for the analysis of multivariate phenotypes and (iii) the availability of major epidemiological and genetic data sets (phenotypes and genotypes). Fellows may participate in ongoing Genome-Wide Association Studies (GWAS) of Schizophrenia, Bipolar Disorder, Alzheimer's Disease, Autism, ADH, Electrophysiological measures of CNS activity, Personality traits and Nicotine Dependence. We anticipate analysis of sequence data to become a future emphasis. Preceptors in this program have many federally and non-federally funded grants providing many opportunities for training in all aspects of Psychiatric Genetics. The program is located in one of the nation's leading Medical Schools with a rich array of basic and applied genetic research studies and educational opportunities. Thus, we expect the long tradition of successful mentoring and research training of scientists and physician-scientists from diverse intellectual backgrounds to continue.