Tissue Level Deformations of the Loaded Spine in Humans with Low Back Pain

项目摘要/摘要 应聘者：应聘者目前是华盛顿大学整形外科助理教授 圣路易斯大学。他拥有生物医学工程博士学位，之前曾在美国国立卫生研究院完成 NRSA F32博士后研究基质金属蛋白酶-13在骨细胞调节中的作用 骨骼动态平衡。他的长期目标是将成功的研究企业发展成为一家翻译公司 肌肉骨骼研究人员调查危险因素(如糖尿病和其他代谢因素)和 骨骼疾病的发病机制。这个拟议的项目将为候选人提供一个 提高了对下腰痛的理解，以及设计、实施和协作人类- 基础研究。该项目的完成有望产生一项令人兴奋和创新的研究 方向，使候选人能够开拓出一个独立的利基市场，并使他获得持久的 校外资金。 导师和咨询委员会：导师委员会由首席导师琳达·范·迪伦博士领导， 圣路易斯华盛顿大学的临床医生兼科学家P.T.博士说。她是世界上最具影响力的 腰背痛患者的测量和分类。其他导师包括萨姆·沃德博士，P.T. 他是世界上使用开放式直立磁共振成像技术的先驱专家之一。 Mathew Silva博士，Julia&Walter Peterson骨科教授，在 骨骼组织成像和生物力学，将为图像处理、研究策略和职业生涯提供建议 发展。Lori Setton博士，Lucy&Stanley Lopata生物医学杰出教授 工程学，将提供椎间盘机械生物学和生物力学方面的专业知识，以及职业生涯 发展和赠款写作。候选人还组建了一支顾问团队，以提供专业知识 项目：Munish Gupta博士，医学博士(杰出的脊柱外科医生)，以表彰他在临床表现中的洞察力 Asem Sharma博士(神经放射科医生)，表彰他在退行性腰痛分类中的见解 脊椎结构；以及Kishan Yalavarthi医学博士(开放直立医院的放射科医生兼医学主任 密苏里州核磁共振中心)将为序列优化和图像解释提供支持。 环境：已为应聘者提供至少1500平方英尺的实验室空间(4000平方英尺的共享空间 Silva博士和Thomopoulos博士实验室小组之间的空间)在肌肉骨骼研究中心(MRC- NIH P30 AR057235)。他可以接触到肌肉骨骼结构 和STANCE CORE(唐博士兼任副主任)； 和老鼠遗传核心。在考生的住处附近有14个肌肉骨骼研究实验室 同一楼层采用开放空间形式，这使得大量资源和大量资源 分享。Van Dillen博士是肌肉骨骼分析实验室的负责人，该实验室与唐博士的 实验室和办公室。实验室是用来用仪器测量受试者的。该实验室还 包括一间私人考场。在这里，人们完成自我报告措施，参与采访和 使用临床措施进行测试，例如我们的标准化临床检查，并在 准备仪表化测试。该实验室配备了一台基于视频的三维摄像机 运动捕捉系统，配有8个MX-T40 2000赫兹红外摄像机。范·迪伦医生承诺从4个月开始 受试者招募的临床设施和所有设施都位于4444森林公园大楼附近 将在那里进行检查和实验室测试。所有4个地点都是华盛顿的一部分 大学医学院，附属于巴恩斯犹太医院和华盛顿大学学院 内科门诊部。 培训计划：培训计划包括设计和执行以人为本的研究的实践培训 按照范·迪伦医生的指示。授课培训包括临床研究培训中心的课程作业 包括伦理学、流行病学和结果研究的课程。华盛顿大学提供了一个 为研讨会和协作互动提供丰富的学术环境。最后，定期与 席尔瓦博士、塞顿博士和沃德博士的导师将指导职业发展并讨论发现。 研究：唐博士将在同种亚群的非特异性低血压人群中检查负重的脊柱 背痛，使用临床检查数据和运动学指标进行分类。随后，这些人将 使用开放式直立磁共振T2加权序列进行成像，检查脊柱在 已加载和未加载状态。预计拟议的研究将确定骨盆的变形变化 加载脊椎以及如何使用LBP改变它们。长期目标是定义多尺度临床 将临床检查结果和相关的LBP病理生理学联系起来的工具；并使用这些工具 研究结果，以指导临床和康复策略。 对应聘者的机构承诺：应聘者在 圣路易斯华盛顿大学整形外科，它提供了一个新翻修的 实验室、启动方案和对工作人员/博士后的支持。

Project Summary/Abstract Candidate: The Candidate is currently an Assistant Professor in Orthopaedic Surgery at Washington University in St. Louis. He holds a Ph.D. in Biomedical Engineering and has previously completed a NIH NRSA F32 Postdoctoral Fellowship examining the role of Matrix Metalloprotease-13 in the osteocyte-mediated bone homeostasis. His long-term goal is to develop successful research enterprise as a translational musculoskeletal researcher to investigate the risk factors (such as diabetes and other metabolic factors) and the disease mechanisms of skeletal disorders. This proposed project would provide to the candidate an improved understanding of low back pain, as well as the ability to design, conduct, and collaborate on human- based studies. The completion of the project is expected to generate an exciting and innovative research direction to enable the Candidate to carve out an independent niche and position him to secure sustained extramural funding. Mentor and Advisory Committee: The mentoring committee is lead by primary mentor, Dr. Linda Van Dillen, P.T., Ph.D., a clinician-scientist at Washington University in St Louis. She is an international leader in the measurement and classification of people with low back pain. Other mentors include Dr. Sam Ward, P.T., Ph.D., one of the pioneering experts in the world in the use of Open, Upright Magnetic Resonance Imaging. Dr. Mathew Silva, Ph.D., Julia & Walter Peterson Professor in Orthopaedics, has extensive experience in the imaging of skeletal tissues and biomechanics, will advise on image processing, research strategies, and career development. Dr. Lori Setton, Ph.D. Lucy & Stanley Lopata Distinguished Professor of Biomedical Engineering, will provide expertise in intervertebral disc mechanobiology and biomechanics, as well as career development and grant writing. The candidate has also assembled a team of consultant to lend expertise to the project: Dr. Munish Gupta, M.D. (Distinguished spine surgeon) for his insights in clinical presentations of low back pain; Dr. Aseem Sharma, M.D. (neuroradiologist) for his insights in the degenerative classification of the spinal structures; and Dr. Kishan Yalavarthi, M.D. (radiologist and medical director for the Open Upright MRI Center of Missouri) who will provide support for sequence optimization and image interpretation. Environment: The candidate has been provided at least 1,500 sq ft of laboratory space (4,000 sq ft of shared space between the Dr. Silva and Dr. Thomopoulos lab groups) in the Musculoskeletal Research Center (MRC - NIH P30 AR057235) at Washington University in St Louis. He has access to the Musculoskeletal Structure and Strength Core (where Dr. Tang also serves as the Associate Director); In Situ Molecular Analysis core; and Mouse Genetics core. There are 14 musculoskeletal research labs adjacent to the candidate's space on the same floor utilizing an open space format, which enable substantial resource and substantial resource sharing. Dr. Van Dillen directs the Musculoskeletal Analysis Lab which is in close proximity to Dr. Tang's laboratory and office. The lab is used for testing of subjects with instrumented measures. The laboratory also includes a private examination room. Here people complete self-report measures, participate in interviews and testing using clinical measures, such as our standardized clinical examination, and change their clothes in preparation for instrumented testing. The laboratory is equipped with a 3-dimensional, video-based Vicon motion capture system with 8, MX-T40 2000 Hz infrared cameras. Dr. Van Dillen has a commitment from 4 clinical facilities for subject recruitment and all are located in close proximity to the 4444 Forest Park Building where examination and laboratory testing will take place. All 4 of the sites are a part of the Washington University School of Medicine and affiliated with the Barnes-Jewish Hospital and Washington University School of Medicine outpatient clinics. Training Plan: The training plan includes practical training in the design and execution of human-based studies as instructed by Dr. Van Dillen. Didactic training includes course work from Clinical Research Training Center and includes courses in ethics, epidemiology, and outcomes research. Washington University provides an academically rich environment for seminars and collaborative interactions. Finally, regular meetings with mentors Drs. Silva, Setton, and Ward will guide career development and discuss findings. Research: Dr. Tang will examine the loaded spine in homogenous subgroups of people with non-specific low back pain, classified using clinical examination data and kinematic metrics. Subsequently, these individuals will be imaged using the Open, Upright MRI with a T2-weighted sequence to examine changes in the spine during loaded and non-loaded states. The proposed studies are expected to identify the deformational changes of the loaded spine and how they are altered with LBP. The long-term objective is to define the multiscale clinical tools that relate clinical examination findings and the associated pathophysiology in LBP; and using these findings to guide clinical and rehabilitation strategies. Institutional Commitment to the Candidate: The Candidate holds a tenure-track faculty position in the Department of Orthopaedics at Washington University in St Louis, which has provided a newly renovated laboratory, start-up package, and support for staff/postdocs.