2016 Antibody Biology and Engineering Gordon Research Conference & Gordon Research Seminar

 描述（由申请人提供）：本申请寻求对将于2016年3月20日至28日在德克萨斯州加尔维斯顿的加尔维斯顿酒店举行的2016年抗体生物学和工程戈登研究会议（GRC）以及伴随的戈登研究研讨会（GRS）的部分支持。这是第四届GRC和第二届GRS，代表了社区中非常令人兴奋和有影响力的会议。本次会议的目的是提供在抗体生物学和工程的快速发展领域的重要的最新发展的深入报道，在一个非正式的设置，旨在最大限度的讨论和互动。这一领域对各种生物学和临床重要主题具有广泛的影响。GRS将在GRC之前立即运行，并将专门为研究生和博士后科学家提供研讨会和海报会议，让他们展示和讨论他们的研究。一位全球遥感中心的主旨发言人将与全球遥感中心的主席一起，通过指导会议和在全球遥感中心会议期间与学员的持续互动提供支持和建议。从基础研究到临床应用的主题，以及来自学术界和工业界的科学家的动态组合，GRC将举办约26 - 30场特邀演讲。还设想了另外10 - 14个简短的演讲，主要来自将从提交的摘要中选出的年轻科学家。GRC还将包括4个海报会议。GRC计划邀请两名主旨发言人，一名来自学术界，一名来自工业界，他们都是各自领域的国际公认专家。为GRC计划的主题包括：A。抗体 与功能相关的结构和动力学; B.修饰抗体多样性-它的产生和使用; C.抗体和受体的功能，通过它们的运作; D。致病性或保护性抗体的发展和机制;抗体生物工程的独特治疗前景，特别是双特异性抗体的作用;共选择抗体作为递送媒介物，以及; G.应用抗体改变疾病的治疗挑战和机遇。该会议将报告在国际努力的前沿研究活动的最新未发表的进展，该领域与临床治疗特别相关，因为许多进入临床或正在开发的新药都是基于免疫球蛋白或其衍生物。在本系列前三次会议的特点是创造性的制药行业互动的悠久历史的基础上，这个GRC和GRS将为来自世界各地的学术和生物制药研究人员提供一个理想的机会，以建立网络并建立新的合作。我们设想，新的治疗应用很可能从这种思想的交叉授粉中产生。此外，通过为年轻的研究人员提供机会，展示他们的研究成果，并与学术界和工业界的资深科学家讨论他们的工作，本次会议将成为这一迅速崛起的领域未来科学领导者发展的重要跳板。

 DESCRIPTION (provided by the applicant): This application seeks partial support for the 2016 Gordon Research Conference (GRC) on Antibody Biology and Engineering, together with an accompanying Gordon Research Seminar (GRS) to be held on March 20 -28, 2016 at the Hotel Galvez in Galveston, Texas. This is the fourth GRC and the second GRS on this topic which is representative of a highly exciting and influential meeting in the community. The aim of this meeting is to provide in-depth coverage of important recent developments in the rapidly evolving field of antibody biology and engineering in an informal setting designed for maximal discussion and interaction. This field has broad implications for a wide variety of biologically an clinically important topics. The GRS will run immediately prior to the GRC and will provide seminar and poster sessions specifically for graduate students and post-doctoral scientists to allow them to present and discuss their research. A GRS keynote speaker, together with the GRC chairs, will offer support and advice through a mentorship session and continuous interactions with the trainees during the course of the GRS meeting. Spanning topics from basic research through to clinical applications and having a very dynamic mix of scientists from academia and industry, the GRC will host approximately 26-30 talks from invited speakers. A further 10-14 shorter talks that are primarily from young scientists that will be selected from submitted abstracts is also envisioned. The GRC will also incorporate 4 poster sessions. The GRC plans on two keynote speakers, 1 from academia and 1 from industry, both of whom are internationally recognized experts in their respective areas. The topics that are planned for the GRC include: A. Antibody structure and dynamics in relations to function; B. Modifying antibody diversity - it's generation and uses; C. The functionality of antibodies and the receptors through which they operate; D. Development and mechanisms of pathogenic or protective antibodies; E. Unique therapeutic vistas in antibody biology engineering and specifically the role of bispecific antibodies; F. Co-opting antibodies as a delivery vehicle, and; G. Therapeutic challenges and opportunities in the application of antibodies to modify disease. The conference will report the most recent unpublished advances in research activity at the leading edge of international efforts in a field that has particular relevance to clinical treatment in that many new drugs reaching the clinic or in development are based on immunoglobulins or their derivatives. Building on the long history of creative academia-industry interactions which have characterized the three previous meetings in this series, this GRC and GRS will provide an ideal opportunity for academic and bio-pharma researchers from around the world to network and forge new collaborations. We envision that novel therapeutic applications are likely to ensue from this cross pollination of ideas. Furthermore, by providing opportunities for younger researchers to present their studies and discuss their work with more established scientists in both academia and industry, this meeting will act as an important spring board for the development of future scientific leaders in this rapidly emerging field.