Ripple Effect of Lifestyle Intervention During Pregnancy on Partners' Weight

描述（由申请人提供）：针对超重个体的生活方式干预可以对家中未经治疗的超重伴侣产生积极的“涟漪反应”。有趣的是，当干预措施针对妇女时，对伴侣体重的涟漪反应似乎最明显。妇女，特别是母亲，仍然是家庭的主要“营养守门人”。尽管人们普遍认识到母性是行为改变的一个强大动力，但迄今为止还没有研究研究过针对母亲妊娠期体重增加的产前生活方式干预的“涟漪反应”。这项拟议研究的主要目的是确定生活方式干预是否能防止超重/肥胖孕妇的妊娠期体重过度增加，对家中未经治疗的伴侣产生积极的“涟漪反应”。这项拟议的研究是对LIFE-moms联盟（1U 01 HL 114377 -01，PI Patian; 3U 01 DK 094418 - 01 S1，PI Martin和Redman）的两项随机III期临床试验的辅助，这些试验正在检查多组分生活方式干预措施在总共650名超重/肥胖妇女中预防妊娠期体重过度增加的有效性。在这项辅助研究中，将在妊娠伴侣妊娠约13周（入组研究）、妊娠35周以及产后6个月和12个月时评估其伴侣的体重、家庭环境和心理社会行为。我们假设，相对于那些标准护理的孕妇，随机接受生活方式干预的孕妇的伴侣， 一年次要目的是检查伴侣在体重控制行为、家庭环境和心理社会参数方面的改善。该项目具有高度创新性，因为它利用了现有的资助研究，是第一个研究多组分产前干预措施的涟漪反应。该项目也有很大的影响，因为怀孕是家庭行为和环境变化的强大动力;而且，如果发生积极的涟漪反应，肥胖治疗和预防领域可能会超越对个人层面的关注，转向生活方式干预的人际影响。

DESCRIPTION (provided by applicant): Lifestyle interventions targeting overweight individuals can produce positive "ripple" effects on untreated overweight partners in the home. Interestingly, ripple effects on partners' weight appear most pronounced when the interventions target women. Women, and mothers in particular, remain the primary "nutritional gatekeepers" of the home. Despite widespread recognition that motherhood is a powerful motivator for behavior changes, no study to date has examined the "ripple" effects of prenatal lifestyle interventions that target mothers' gestational weight gain. The primary aim of the proposed study is to determine whether lifestyle interventions to prevent excessive gestational weight gain in overweight/obese pregnant women have positive "ripple" effects on untreated partners in the home. The proposed study is ancillary to two randomized phase III clinical trials in the LIFE-moms consortium (1U01HL114377-01, PI Phelan; 3U01DK094418-01S1, PIs Martin and Redman) that are examining the efficacy of multi-component lifestyle interventions to prevent excessive gestational weight gain in a total of 650 overweight/obese women. In this ancillary study, partners' weight, home environment, and psychosocial behaviors will be assessed when their pregnant partners are ~13 weeks gestation (study entry), 35 weeks gestation and at 6 and 12 months postpartum. We hypothesize that partners of pregnant women randomized to the lifestyle intervention, relative to those of standard care, will have greater weight losses through 12-months. Secondary aims examine partner improvements in weight control behaviors, the home environment, and psychosocial parameters. This project is highly innovative, as it capitalizes on existing funded research and is the first study to examine ripple effects of multicomponent prenatal interventions. The project also has high impact, as pregnancy is a powerful motivator for behavior and environmental changes in the home; and, if positive ripple effects occur, the field of obesity treatment and prevention could move beyond focus on individual level to the often unrecognized interpersonal effects of lifestyle interventions.