Administrative Core

行政核心 项目摘要/摘要 MSKCC-康奈尔癌症纳米药物翻译中心(MC2TCN)将建立一个 用于增强基础材料研究的集成，针对特定类别的超小(&lt；10 nm直径) 纳米粒子在肿瘤学领域的转化努力。为了实现这一目标，我们提出了一个 中心内的综合管理核心。这一核心将成为多学科中心的来源 领导，并将管理中心的行政努力，以简化发展高度 集成了新的粒子结构和几何结构，以改进术中癌症诊断和治疗工具 分期，以及提高放射治疗和药物输送产品的疗效。这将需要 开发和/或鉴定新的表征方法、基因工程动物模型、 成像分析工具和定量组织学程序。我们建议的领导层和管理层 该结构确保该中心的研究人员和康奈尔大学、密歇根州立大学和密歇根大学的其他研究人员 密苏里州将可以利用基础设施、人员和专业知识来促进这些 将这些纳米颗粒产品转化为临床及其后续研究的必要进展 商业化。我们已经提出了一个领导和管理结构，将弥补现有的差距 基础研究人员和临床研究人员之间的合作，确保该中心的所有研究人员都能充分利用 关于癌症纳米技术应用的现有和拟议的机构间资源。通过 为实现本节提出的目标，行政核心将向中心提供领导 并将简化管理工作，以加快临床可翻译纳米颗粒的开发 产品。

ADMINISTRATIVE CORE Project Abstract/Summary The MSKCC-Cornell Center for Translation of Cancer Nanomedicines (MC2TCN) will establish an environment for the enhanced integration of basic materials research on specific classes of ultrasmall (<10 nm diameter) nanoparticles with translational efforts in the field of oncology. In order to achieve this goal we propose a comprehensive Administration Core within the Center. This core will be the source of multidisciplinary Center leadership, and will manage the Center's administrative efforts to streamline the development of highly integrated novel particle architectures and geometries to improve intraoperative tools for cancer diagnosis and staging, as well as to enhance the efficacy of radiotherapeutic and drug delivery products. This will require the development and/or identification of new characterization methods, genetically engineered animal models, imaging analysis tools, and quantitative histological procedures. Our proposed leadership and management structure ensures that the Center's investigators and other researchers at Cornell, MSKCC, and University of Missouri will have access to infrastructure, personnel, and expertise that can be used to facilitate these necessary developments for translation of these nanoparticle products into the clinic and their subsequent commercialization. We have proposed a leadership and management structure that will bridge existing gaps between basic and clinical researchers, ensuring that all of the Center's investigators can take full advantage of both the existing and proposed inter-institutional resources for cancer nanotechnology applications. By accomplishing the Aims proposed in this section, the Administrative Core will provide leadership to the Center and will streamline administrative efforts to accelerate the development of clinically translatable nanoparticle products.