Molecular Neuroimaging Symposium

分子神经影像研讨会

• 批准号: 7917104
• 负责人: Michelle S Bradbury
• 金额: $ 1.5万
• 依托单位: SOCIETY OF NUCLEAR MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7917104
• 关键词: Animals; Area; Basic Science; Biological Markers; Biological Process; Blood - brain barrier anatomy; Brain Neoplasms; Cardiovascular system; Caring; Cells; Central Nervous System Diseases; Chemistry; Clinical; Collaborations; Communities; Development; Diagnostic; Discipline; Discipline of Nuclear Medicine; Disease; Early Diagnosis; Engineering; Fostering; Functional disorder; Goals; Growth; Health Care Costs; Image; Imaging technology; Immune; Immunotherapy; Individual; Journals; Link; Measures; Mental disorders; Metabolism; Molecular; Molecular Biology; Molecular Genetics; Monitor; Nerve Degeneration; Neuraxis; Neurosciences; Participant; Pathologic Processes; Phenotype; Physics; Preventive; Process; Public Health; Publishing; Research; Research Personnel; Science; Scientist; Sensory Receptors; Series; Stem cells; Structure; Tracer; United States National Institutes of Health; Work; abstracting; base; clinical application; computational neuroscience; design; drug discovery; follow-up; improved; interest; lectures; meetings; molecular imaging; multimodality; neuroimaging; neurophysiology; novel marker; posters; public health relevance; stem; success; symposium; tumor

DESCRIPTION (provided by applicant): The proposed two-day symposium will bring together individuals from multiple scientific disciplines; including chemistry, engineering, physics, molecular biology, neurosciences, and imaging sciences with the goal of promoting the emerging field of molecular neuroimaging. This meeting follows a similar conference held at NIH in 2009 that focused on cardiovascular molecular imaging. The previous conference attracted over 200 participants and 28 poster presentations. The proposed meeting is designed to continue this momentum and stimulate further growth in the field of molecular imaging. We anticipate attracting individuals from both the basic science and clinical communities, with a special emphasis on encouraging the participation of junior scientists. The overall structure of the meeting will include a series of didactic lectures on focused topics by experts in the field, panel discussions on selected key areas, and an abstract poster session. This symposium will focus on advances in targeted multimodality imaging of the central nervous system (CNS) and will cover imaging of the blood-brain barrier (BBB), tumors, neuroreceptors, stem cells, adoptive immunotherapies, and other biological processes relevant to the CNS. There will be an emphasis on interactions among speakers and registrants to stimulate further interest in this field and foster collaborations between participants. All invited speakers will be required to provide a 2-3 page summary of their presentations which will be provided to the participants and distributed electronically. Abstracts from the poster session will be published in The Journal of Nuclear Medicine or Molecular Imaging. The proceedings will be published as a supplement to The Journal of Nuclear Medicine or Molecular Imaging. The objectives of the meeting are: 1) to educate the scientific community about the potential of targeted multimodality molecular neuroimaging; 2) to provide an overview of critical issues related to development of targeted tracers that can cross the BBB for targeting, monitoring, and/or treating CNS disease; 3) to provide an overview of various imaging technologies for both small animal imaging and clinical molecular imaging; 4) to review the approaches and implications for imaging of stem and/or immune cells; 5) to define the potential of neuroreceptor imaging and imaging of metabolic processes; 6) to provide an overview of the potential of molecular neuroimaging to improve our understanding and management of critical CNS pathophysiological processes, such as neurodegeneration, brain tumors, and psychiatric diseases; 7) to promote basic science research in molecular imaging and clinical applications for CNS disorders; 8) to foster potential collaborations among scientists and clinicians working in various related fields; 9) to stimulate interactions between junior scientists and more established investigators in the field. PUBLIC HEALTH RELEVANCE: There has been a paradigm shift towards the development of a more molecularly-based and personalized approach to the early detection, monitoring, and treatment of central nervous system diseases (CNS) with goals of developing preventive measures as well as controling the escalating costs of healthcare. Parallel advances in many scientific and clinical fields are revolutionizing biomarker development, the design and synthesis of targeted diagnostic probes, drug discovery, and computational neurosciences. Another key aspect of individualized care is obtaining a detailed profile of the pathologic processes of interest through the application of noninvasive molecular imaging technologies over a range of spatial scales, The application of targeted molecular imaging based on novel markers may be linked to distinct molecular/genetic phenotypes, in addition to elucidating pathophysiology that can inform the management of CNS disease/disorders. The proposed two-day symposium will bring together individuals from multiple scientific disciplines; including chemistry, engineering, physics, molecular biology, neurophysiology, and imaging sciences with the goal of promoting the evolving field of translational molecular neuroimaging.

描述（由申请人提供）：拟议的为期两天的研讨会将汇集来自多个科学学科的个人;包括化学，工程，物理，分子生物学，神经科学和成像科学，以促进分子神经成像的新兴领域的目标。这次会议是继2009年在NIH举行的类似会议之后举行的，该会议专注于心血管分子成像。上一次会议吸引了200多名与会者和28个海报介绍。拟议的会议旨在继续这一势头，并刺激分子成像领域的进一步发展。我们希望吸引来自基础科学和临床社区的个人，特别强调鼓励年轻科学家的参与。会议的总体结构将包括一系列由该领域专家就重点主题进行的教学讲座，就选定的关键领域进行小组讨论，以及一个抽象的海报会议。本次研讨会将重点关注中枢神经系统（CNS）靶向多模态成像的进展，并将涵盖血脑屏障（BBB），肿瘤，神经受体，干细胞，过继免疫治疗和其他与CNS相关的生物过程的成像。将强调发言者和登记者之间的互动，以激发对这一领域的进一步兴趣，并促进与会者之间的合作。所有受邀发言者都必须提供一份2-3页的发言摘要，摘要将以电子方式提供给与会者。海报会议的摘要将发表在《核医学或分子成像杂志》上。该论文集将作为《核医学或分子成像杂志》的增刊出版。会议的目的是：1）教育科学界关于靶向多模态分子神经成像的潜力; 2）提供与靶向示踪剂开发相关的关键问题的概述，这些示踪剂可以穿过BBB用于靶向、监测和/或治疗CNS疾病; 3）提供用于小动物成像和临床分子成像的各种成像技术的概述; 4）回顾干细胞和/或免疫细胞成像的方法和意义; 5）定义神经受体成像和代谢过程成像的潜力; 6）提供分子神经成像的潜力的概述，以提高我们对关键CNS病理生理过程的理解和管理，如神经变性、脑肿瘤和精神疾病; 7）促进分子成像和CNS疾病临床应用的基础科学研究; 8）促进在各个相关领域工作的科学家和临床医生之间的潜在合作; 9）刺激初级科学家和该领域更成熟的研究人员之间的互动。 公共卫生关系：已经出现了一种范式转变，即开发一种更基于分子和个性化的方法来早期检测、监测和治疗中枢神经系统疾病（CNS），其目标是制定预防措施以及控制不断上升的医疗保健成本。许多科学和临床领域的平行进展正在彻底改变生物标志物的开发，靶向诊断探针的设计和合成，药物发现和计算神经科学。个体化护理的另一个关键方面是通过在一系列空间尺度上应用非侵入性分子成像技术来获得感兴趣的病理过程的详细概况。除了阐明可以告知CNS疾病/病症的管理的病理生理学之外，基于新标记物的靶向分子成像的应用可以与不同的分子/遗传表型相关联。拟议的为期两天的研讨会将汇集来自多个科学学科的个人;包括化学，工程，物理，分子生物学，神经生理学和成像科学，旨在促进翻译分子神经成像领域的发展。