Molecular Neuroimaging Symposium

描述（由申请人提供）：本次为期两天的研讨会将汇集来自多个科学学科的个人；包括化学、工程、物理、分子生物学、神经科学和成像科学，旨在促进分子神经成像这一新兴领域的发展。这次会议是继2009年在美国国立卫生研究院举行的一次类似的会议之后举行的，该会议的重点是心血管分子成像。上一届会议吸引了200多名与会者和28个海报展示。本次会议旨在延续这一势头，促进分子成像领域的进一步发展。我们期望吸引来自基础科学和临床社区的个人，特别强调鼓励年轻科学家的参与。会议的总体结构将包括由该领域专家就重点主题进行的一系列教学讲座，选定关键领域的小组讨论以及抽象海报会议。本次研讨会将重点讨论中枢神经系统（CNS）靶向多模态成像的进展，并将涵盖血脑屏障（BBB）、肿瘤、神经受体、干细胞、过继免疫疗法和其他与中枢神经系统相关的生物过程的成像。将强调演讲者和注册人之间的互动，以激发对这一领域的进一步兴趣，并促进参与者之间的合作。所有受邀演讲者将被要求提供一份2-3页的演讲摘要，该摘要将提供给与会者并以电子方式分发。海报会议的摘要将发表在《核医学杂志》或《分子成像》上。会议记录将作为《核医学或分子成像杂志》的增刊发表。会议的目的是：1)教育科学界关于靶向多模态分子神经成像的潜力；2)概述与开发靶向示踪剂相关的关键问题，这些示踪剂可以穿过血脑屏障，用于靶向、监测和/或治疗中枢神经系统疾病；3)综述小动物影像学和临床分子影像学的各种影像学技术；4)综述干细胞和/或免疫细胞成像的方法和意义；5)确定神经受体成像和代谢过程成像的潜力；6)概述分子神经影像学的潜力，以提高我们对关键中枢神经系统病理生理过程的理解和管理，如神经退行性疾病、脑肿瘤和精神疾病；7)推动中枢神经系统疾病分子影像学的基础科学研究和临床应用；8)促进在各个相关领域工作的科学家和临床医生之间的潜在合作；9)促进年轻科学家和该领域更成熟的研究者之间的互动。

DESCRIPTION (provided by applicant): The proposed two-day symposium will bring together individuals from multiple scientific disciplines; including chemistry, engineering, physics, molecular biology, neurosciences, and imaging sciences with the goal of promoting the emerging field of molecular neuroimaging. This meeting follows a similar conference held at NIH in 2009 that focused on cardiovascular molecular imaging. The previous conference attracted over 200 participants and 28 poster presentations. The proposed meeting is designed to continue this momentum and stimulate further growth in the field of molecular imaging. We anticipate attracting individuals from both the basic science and clinical communities, with a special emphasis on encouraging the participation of junior scientists. The overall structure of the meeting will include a series of didactic lectures on focused topics by experts in the field, panel discussions on selected key areas, and an abstract poster session. This symposium will focus on advances in targeted multimodality imaging of the central nervous system (CNS) and will cover imaging of the blood-brain barrier (BBB), tumors, neuroreceptors, stem cells, adoptive immunotherapies, and other biological processes relevant to the CNS. There will be an emphasis on interactions among speakers and registrants to stimulate further interest in this field and foster collaborations between participants. All invited speakers will be required to provide a 2-3 page summary of their presentations which will be provided to the participants and distributed electronically. Abstracts from the poster session will be published in The Journal of Nuclear Medicine or Molecular Imaging. The proceedings will be published as a supplement to The Journal of Nuclear Medicine or Molecular Imaging. The objectives of the meeting are: 1) to educate the scientific community about the potential of targeted multimodality molecular neuroimaging; 2) to provide an overview of critical issues related to development of targeted tracers that can cross the BBB for targeting, monitoring, and/or treating CNS disease; 3) to provide an overview of various imaging technologies for both small animal imaging and clinical molecular imaging; 4) to review the approaches and implications for imaging of stem and/or immune cells; 5) to define the potential of neuroreceptor imaging and imaging of metabolic processes; 6) to provide an overview of the potential of molecular neuroimaging to improve our understanding and management of critical CNS pathophysiological processes, such as neurodegeneration, brain tumors, and psychiatric diseases; 7) to promote basic science research in molecular imaging and clinical applications for CNS disorders; 8) to foster potential collaborations among scientists and clinicians working in various related fields; 9) to stimulate interactions between junior scientists and more established investigators in the field. PUBLIC HEALTH RELEVANCE: There has been a paradigm shift towards the development of a more molecularly-based and personalized approach to the early detection, monitoring, and treatment of central nervous system diseases (CNS) with goals of developing preventive measures as well as controling the escalating costs of healthcare. Parallel advances in many scientific and clinical fields are revolutionizing biomarker development, the design and synthesis of targeted diagnostic probes, drug discovery, and computational neurosciences. Another key aspect of individualized care is obtaining a detailed profile of the pathologic processes of interest through the application of noninvasive molecular imaging technologies over a range of spatial scales, The application of targeted molecular imaging based on novel markers may be linked to distinct molecular/genetic phenotypes, in addition to elucidating pathophysiology that can inform the management of CNS disease/disorders. The proposed two-day symposium will bring together individuals from multiple scientific disciplines; including chemistry, engineering, physics, molecular biology, neurophysiology, and imaging sciences with the goal of promoting the evolving field of translational molecular neuroimaging.