Risk for Reactive Aggression into Adolescence: Emotional Reactivity and Parenting

7.项目总结/摘要 我的研究植根于发展心理病理学框架， 影响青少年攻击性发展和持续的机制，长期目标是 将这些知识转化为更有效的预防和干预措施。之时尚 临床转诊的青少年中的攻击行为以及有据可查的相关风险说明了紧迫性 需要开展研究，查明儿童和家庭风险机制，以更好地确定谁最脆弱， 如何最好地干预这些青年及其家庭。目前的建议旨在审查情绪 反应性作为一种神经生物学脆弱性的持续反应性侵略（RA）在关键的 过渡到青春期，这一时期的特点是神经生物学的实质性变化， 情感发展此外，它旨在评估动态父子事务如何用于 随着时间的推移，类风湿关节炎会加剧，因为在这个发育时期，养育子女对高危青少年可能特别有效 敏感期。此应用程序详细介绍了一个全面的培训计划，使我能够解决这些问题 问题，并以几个重要的方式建立在我以前的经验之上。第一，由于异质性 在从事攻击性行为的年轻人中，我的目标是研究更具体的 攻击行为表型，即RA，在过渡到青春期，一个快速的时间， 神经生物学变化其次，我寻求扩大我的神经生物学评估模式的知识， RA潜在机制的心理生理学评估。第三，希望掌握加工工艺， 分析生态瞬时评估作为一种创新的工具，全面评估RA及其 日常生活中的潜在机制。与NIMH战略优先事项2.1和2.2一致，当前提案 采取了一种交易的方法，并通过利用多模式， 在过渡期对RA、情绪反应和养育进行生态学评估， 青春期情绪反应和父母教养的个体差异的独立和交互作用 将在临床高危人群中测试18个月以上RA发展和持续性的维度。 青春的样本本研究的目的是：1）调查与下列因素之间的并发和前瞻性关联： 在向青春期过渡期间，情绪反应和RA的个体差异; 2）检查双 18个月内父母对情绪反应和RA反应的方向性; 3）评估父母对情绪反应和RA反应的方向性。 作为情绪反应和类风湿关节炎之间的关联的调节剂的情绪反应。的 这一建议的中心假设是，从多方面衡量， 赋予风险的持续性类风湿性关节炎进入青春期，与变化的父母对情绪的反应， 反应性和RA有助于加剧或改善这种关联。这些知识最终可以用于 进一步制定这些具体进程的预防和干预目标。

7. Project Summary/Abstract My research is rooted in a developmental psychopathology framework and focuses on understanding mechanisms that influence the development and persistence of aggression in youth, with the long-term goal of translating this knowledge to develop more effective prevention and intervention efforts. The prevalence of aggression among clinically referred youth and the well-documented associated risks speaks to the urgent need for research to identify child and familial risk mechanisms to better determine who is most vulnerable and how to best intervene with those youth and their families. The current proposal seeks to examine emotional reactivity as a neurobiological vulnerability for the persistence of reactive aggression (RA) during the critical transition to adolescence, a time period marked by substantial changes in the neurobiology underlying emotional development. Additionally, it aims to assess how dynamic parent-child transactions may serve to exacerbate RA over time, as parenting may be particularly potent for at-risk youth during this developmentally sensitive period. This application details a comprehensive training plan that allows me to address these questions and build on my previous experiences in several important ways. First, in light of the heterogeneity among youth engaging in aggressive behaviors, I aim to examine mechanisms underlying a more specific behavioral phenotype of aggression, namely RA, during the transition to adolescence, a time of rapid neurobiological change. Second, I seek to expand my knowledge of neurobiological assessment modalities to psychophysiological assessment of mechanisms underlying RA. Third, I hope to master the processing and analysis of ecological momentary assessments as an innovative tool to comprehensively assess RA and its underlying mechanisms in daily life. Concordant with NIMH strategic priorities 2.1 and 2.2, the current proposal takes a transactional approach and focuses on within-individual differences by utilizing a multi-modal, ecologically informed assessment of RA, emotional reactivity and parenting during the transition to adolescence. Independent and interactive effects of individual variation in emotional reactivity and parenting dimensions on the development and persistence of RA over 18 months will be tested in a clinically at-risk sample of youth. The aims of the study are 1) investigate concurrent and prospective associations between individual variation in emotional reactivity and RA during the transition to adolescence; 2) examine the bi- directional nature of parental response to emotional reactivity and RA over 18 months; 3) assess parental response to emotional reactivity as a moderator of the association between emotional reactivity and RA. The central hypothesis of this proposal is that heightened emotional reactivity as measured multidimensionally confers risk for the persistence of RA into adolescence, with variation in parental response to emotional reactivity and RA serving to exacerbate or ameliorate this association. This knowledge can ultimately be used to further develop prevention and intervention targets for these specific processes.