Administrative Core

行政核心的主要作用是评估和协调三个研究项目和参与中心提案的多个机构之间的研究进展。项目1将确定IFN-拮抗剂-宿主因子相互作用的结构/生化基础，并确定这些相互作用对DC成熟和功能的影响。项目2将解决以下假设：由EBOV和MARV感染诱导的DC的破坏的成熟将导致T细胞活化受损和T细胞功能异常/缺失，并且丝状病毒IFN拮抗剂蛋白的机制对这些结果做出关键贡献。项目3将表征体内丝状病毒感染期间树突状细胞和淋巴细胞的表型和功能状态。这些研究将在四个不同的机构由七个不同的实验室进行。为确保该综合研究计划的进展最大化，行政核心（核心A）将负责以下角色：协调：每周（至少）研究项目的PI和核心之间的电话会议;每月一次（至少）定期举行基于网络的实验室间会议，以交流和评价数据;以及所有参与小组和科学咨询委员会（SAB）成员之间的年度会议，以评估科学进展。这些会议将促进不同实验室之间的试剂和科学交流。它还将协调每年参加年度国家IMVC计划会议。此外，行政当局将协调预算问题。它将协助研究者准备手稿并向NIH提交年度进展报告。它还将维持一个网站，用于传播与这一项目有关的数据，并促进数据共享和遵守规章。核心A将包括一名专门为此目的聘请的管理员和托马斯莫兰博士，他是一名有成就的病毒免疫学家，曾担任多研究者中心赠款的主要研究者。Moran博士将为Basler博士提供建议，Basler博士将担任总体PI和主管或核心A。

The main role of the Administration Core is to evaluate and coordinate advances in the research among the three research projects and multiple institutions participating in the Center proposal. Project 1 will define the structural/biochemical basis for IFN-antagonist-host factor interactions and define the impact of these interactions on DC maturation and function. Project 2 will address the hypotheses that that the disrupted maturation of DCs induced by EBOV and MARV infection will lead to impaired T cell activation and aberrant/absent T cell function and that the mechanisms of the filoviral IFN-antagonist proteins make key contributions to these outcomes. Project 3 will characterize the phenotype and functional status of dendritic cells and lymphocytes during filovirus infection in vivo. These studies will be carried out at four different institutions by seven different laboratories. To ensure that the progress of this integrated research program will be maximized, the Administration Core (Core A) will be responsible for the following roles: Coordinate: weekly (at a minimum) teleconferences between the Pis of the research projects and cores; monthly (at a minimum) scheduled web-based interlab meetings to exchange and critique data; and an Annual Meeting among members of all participating groups and the Scientific Advisory Board (SAB) to assess scientific progress. These meetings will facilitate reagent and scientific exchanges between the different laboratories. It will also coordinate annual participation in the annual National IMVC Program meeting. In addition, the Administration will coordinate budget issues. It will assist the investigators with manuscript preparation and submission of annual progress reports to the NIH. It will also maintain a web site for data dissemination in connection with this project and facilitate data sharing and regulatory compliance. Core A will include an Administrator, hired specifically for this purpose and Dr. Thomas Moran, an accomplished viral immunologist with significant prior experience serving as PI of multi-investigator Center grants. Dr. Moran will provide advice to Dr. Basler who will serve as overall PI and supervisor or Core A.