Mouse Breeding and Procedure Core

核心C，小鼠育种和显微外科和程序核心将继续服务于所有三个项目 在整个五年的计划中。Core C有两个主要功能：（1）小鼠育种和 管理单位将继续提供转基因和无效小鼠培育成特定的遗传背景， 该计划的三个项目。该单位将提供交配和动物基因分型服务 项目1-2-3所需。(2)新成立的小鼠显微外科和手术部门已经从 扩大该计划的研究。该单位的目标是标准化所有显微外科手术程序 项目实施的程序。该单位将负责致命辐射和骨 骨髓移植（项目2），股动脉结扎诱导后肢缺血（项目2）， 胆固醇逆向转运（项目1）和心肌梗死（项目3）的评估。

Core C, the Mouse Breeding and Microsurgery and Procedure Core will continue to serve all three Projects over all five years of the Program. There are two major functions of Core C: (1) The Mouse Breeding & Management Unit will continue to provide transgenic and null mice bred Into specific genetic backgrounds to each of the three projects of the Program. This Unit will provide sen/ices to mate and genotype the animals required for Projects 1-2-3. (2) The newly-formed Mouse Microsurgery and Procedure Unit has grown out of the expansion of the Program's studies. The goal of this Unit is to standardize all microsurgery procedures and procedures carried out by the Projects. This Unit will be responsible for lethal irradiation and bone marrow transplantation (Projects 2), femoral artery ligation for induction of hind limb ischemia (Project 2), assessment of reverse cholesterol transport (Project 1) and myocardial infarction (Project 3).