Linking genomics of Burkholderia pseudomallei to melioidosis: diversity of clinical manifestations, changing epidemiology and microevolution in chronic carriage.

达尔文前瞻类梅毒研究自1989年以来记录了761例，其中102人死亡。这项研究改善了治疗和公共卫生倡议。对细菌全基因组进行测序的新技术为确定城市类鼻疽病增加的原因提供了机会，并分析了这组独特的22年以上的细菌及其相关的患者数据，以找到重要的细菌毒力因素，为未来的诊断、治疗和疫苗奠定了基础。

The Darwin Prospective Melioidosis Study has documented 761 cases since 1989, with 102 fatalities. This study has led to improved therapy and public health initiatives. New technology to sequence whole bacterial genomes provides an opportunity to determine why urban melioidosis is increasing and to analyse this unique 22+ year set of bacteria and their linked patient data to find the important bacterial virulence factors, forming a foundation for future diagnostics, therapeutics, and vaccines.