Training for Transformative Discovery in Psychiatry

 描述（由申请人提供）：本提案请求支持T32 MH 16804（36-40年级）的延续。最近的更新（31-35年级）建议通过将培训重点从主要的临床研究转移到提供转化神经科学研究培训来重振这一长期成功的T32。我们现在可以报告说，这一转变非常成功，这一点可以从一些指标中得到证明：招募了翻译神经科学研究人员，包括增加了医学博士的数量，博士受训人员、女性受训人员、少数族裔受训人员和残疾受训人员;毕业生获得第一笔赠款的比率高;研究质量（以被任命者发表论文的期刊的影响因素衡量）;以及毕业生的成功安置。T32 MH 16084的成就反映在匹兹堡大学精神病学系翻译神经科学项目学院的大幅扩张，以及优秀申请人数量的相应增加，因此每年符合条件的申请人数量超过了我们的10倍。因此，我们希望将目前申请中的博士后实习生名额扩大到五个。这将为这些优秀的候选人提供机会，并为转化神经科学培训活动提供更大的“临界质量”。所有学员都受益于我们在转化神经科学方面的既定培训计划，该计划旨在提供技术和策略方面的实用培训，以便学员的研究成果可以在多个发现层面上进行转化。接受过基础神经科学培训的受训者进一步接受临床暴露，旨在帮助他们在精神疾病的临床、病理生理学和病理学表现方面发展“流利性”，并且;接受过临床培训的个人增强他们在基础神经科学知识方面的“流利性”。此外，我们的学员受益于个性化培训计划的制定和参与我们非常成功的职业和研究发展课程。T32 MH 16804继续由Robert A.亲爱的医学博士一位高级转化神经科学研究者，有着优秀的转化神经科学研究者指导记录。斯威特博士将由新的联合主任玛丽L.医学博士菲利普斯，M.D.（Cantab），高级临床和转化神经科学研究员， 影像神经科学研究者的著名导师。我们的课程教师已经丰富了许多研究人员，他们为精神疾病的转化神经科学研究带来了许多额外的最先进的方法。通过将过去34年来成功培训精神病学研究人员的良好记录与过去4年资助期间开发的新发现和新方法相结合，T32 MH 16804现在准备通过准备扩大翻译神经科学家的队列来影响该领域，以在精神病学方面取得变革性发现。

 DESCRIPTION (provided by applicant): This proposal requests support for continuation of T32 MH16804 (Years 36-40). The most recent renewal (Years 31-35) proposed to reinvigorate this long term successful T32 by shifting the emphasis of training from predominantly clinical research to one providing translational neuroscience research training. We can now report that this transition has been highly successful as evidenced by a number of metrics: recruitment of translational neuroscience investigators, including increased numbers of M.D., Ph.D. trainees, female trainees, minority trainees, and trainees with disabilities; high rates of first grant fundig of graduates; research quality (as measured by the impact factor of journals in which appointees have published), and; successful placement of graduates. The achievements of T32 MH16084 have been mirrored by a substantial expansion of the Faculty of the Translational Neuroscience Program within the Department of Psychiatry at the University of Pittsburgh, and a corresponding increase in the number of outstanding applicants, such that the annual number of eligible applicants has exceeded our slots 10-fold. As a result, we look to expand the number of postdoctoral trainee slots in the current application to a total of five. This will afford opportunties to these many outstanding candidates and provide a greater "critical mass" for translational neuroscience training activities. All trainees benefit from our established training program in translational neuroscience which has been designed to provide practical training in techniques and strategies such that trainees' resulting research can be translated across multiple levels of discovery. Trainees with prior basic neuroscience training further receive clinical exposures designed to help them develop "fluency" in the clinical, pathophysiologic, and pathologic manifestations of mental illness, and; clinically trained individuals enhance their "fluency" in basic neuroscience knowledge. In addition, our trainees benefit from the development of individualized training plans and from participation in our highly successful Career and Research Development curriculum. T32 MH16804 continues to be led by Robert A. Sweet, M.D., a senior translational neuroscience investigator with a record of outstanding mentorship of translational neuroscience investigators. Dr. Sweet will be supported by new Co- Director, Mary L. Phillips, M.D., M.D. (Cantab), a senior clinical and translational neuroscience investigator and acclaimed mentor of imaging neuroscience investigators. Our Program Faculty has been enriched by a number of investigators who bring many additional state of the art approaches to translational neuroscience studies of mental illness. By combining the strong track record in the successful training of psychiatry researchers established during the past 34 years with the emphasis on new discovery and new methodologies developed during the past 4 years of funding, T32 MH16804 is now poised to impact the field by preparing an expanded cohort of translational neuroscientists to make transformative discoveries in psychiatry.